TY - JOUR
T1 - Electrochemical detection and sensing of reactive oxygen species
AU - Yuasa, Makoto
AU - Oyaizu, Kenichi
PY - 2005/11
Y1 - 2005/11
N2 - Reactive oxygen species (ROS) such as superoxide anion radical (O2-·) play an essential role on normal cellular growth and homeostasis. However, excess ROS generated by perturbing O2-· homeostasis under various conditions of oxidative stress induce high radical toxicity, resulting in many diseases such as cancer, brain and myocardial infarction, and inflammation. Quantitative analysis of O2-· by a convenient method is a subject of intense research, since most of ROS are derived from O2-·. In situ real-time measurement of O2-· is very important to understand the relevance of ROS to many diseases. Recent progress in electrochemical sensors for the facile detection of O2-·, including biosensors utilizing a variety of metalloproteins as sensing elements for O2-· and very recently developed all-synthetic sensors with a high selectivity for O2-· detection, is reviewed. Emphasis is placed on the possibility of the all-synthetic sensor for convenient in vivo measurement of ROS.
AB - Reactive oxygen species (ROS) such as superoxide anion radical (O2-·) play an essential role on normal cellular growth and homeostasis. However, excess ROS generated by perturbing O2-· homeostasis under various conditions of oxidative stress induce high radical toxicity, resulting in many diseases such as cancer, brain and myocardial infarction, and inflammation. Quantitative analysis of O2-· by a convenient method is a subject of intense research, since most of ROS are derived from O2-·. In situ real-time measurement of O2-· is very important to understand the relevance of ROS to many diseases. Recent progress in electrochemical sensors for the facile detection of O2-·, including biosensors utilizing a variety of metalloproteins as sensing elements for O2-· and very recently developed all-synthetic sensors with a high selectivity for O2-· detection, is reviewed. Emphasis is placed on the possibility of the all-synthetic sensor for convenient in vivo measurement of ROS.
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U2 - 10.2174/138527205774610921
DO - 10.2174/138527205774610921
M3 - Review article
AN - SCOPUS:27644511925
SN - 1385-2728
VL - 9
SP - 1685
EP - 1697
JO - Current Organic Chemistry
JF - Current Organic Chemistry
IS - 16
ER -
