Electrochemical molecular sieving of the polyion complex film for designing highly sensitive biosensor for creatinine

Tetsuya Osaka; Shinichi Komaba; Akio Amano; Yusuke Fujino; Hiroshi Mori

doi:10.1016/S0925-4005(99)00423-2

Electrochemical molecular sieving of the polyion complex film for designing highly sensitive biosensor for creatinine

Tetsuya Osaka, Shinichi Komaba, Akio Amano, Yusuke Fujino, Hiroshi Mori

Research Organization for Nano & Life Innovation

Research output: Contribution to journal › Conference article › peer-review

42 Citations (Scopus)

Abstract

On the basis of our success on creatinine sensor composed of immobilization of creatinine iminohydrolase by polyion complexes (PIC) with a combination of interfacial pH change detection by using inactive polypyrrole film, we investigated various combination of PIC and their sensitivities. The sensitivity of the creatinine sensor was dependent strongly on the distance of the functional units of the anionic species of PIC. The dependence of sensitivity was related to the molecular sieving of the PIC used for the immobilization of the enzyme, i.e., the diffusion of the analytes in the PIC.

Original language	English
Pages (from-to)	58-63
Number of pages	6
Journal	Sensors and Actuators, B: Chemical
Volume	65
Issue number	1
DOIs	https://doi.org/10.1016/S0925-4005(99)00423-2
Publication status	Published - 2000 Jun 30
Event	IMCS-7: 7th International Meeting on Chemical Sensors - Beijing, China Duration: 1998 Jul 27 → 1998 Jul 30

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

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10.1016/S0925-4005(99)00423-2

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abstract = "On the basis of our success on creatinine sensor composed of immobilization of creatinine iminohydrolase by polyion complexes (PIC) with a combination of interfacial pH change detection by using inactive polypyrrole film, we investigated various combination of PIC and their sensitivities. The sensitivity of the creatinine sensor was dependent strongly on the distance of the functional units of the anionic species of PIC. The dependence of sensitivity was related to the molecular sieving of the PIC used for the immobilization of the enzyme, i.e., the diffusion of the analytes in the PIC.",

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T1 - Electrochemical molecular sieving of the polyion complex film for designing highly sensitive biosensor for creatinine

AU - Osaka, Tetsuya

AU - Komaba, Shinichi

AU - Amano, Akio

AU - Fujino, Yusuke

AU - Mori, Hiroshi

PY - 2000/6/30

Y1 - 2000/6/30

N2 - On the basis of our success on creatinine sensor composed of immobilization of creatinine iminohydrolase by polyion complexes (PIC) with a combination of interfacial pH change detection by using inactive polypyrrole film, we investigated various combination of PIC and their sensitivities. The sensitivity of the creatinine sensor was dependent strongly on the distance of the functional units of the anionic species of PIC. The dependence of sensitivity was related to the molecular sieving of the PIC used for the immobilization of the enzyme, i.e., the diffusion of the analytes in the PIC.

AB - On the basis of our success on creatinine sensor composed of immobilization of creatinine iminohydrolase by polyion complexes (PIC) with a combination of interfacial pH change detection by using inactive polypyrrole film, we investigated various combination of PIC and their sensitivities. The sensitivity of the creatinine sensor was dependent strongly on the distance of the functional units of the anionic species of PIC. The dependence of sensitivity was related to the molecular sieving of the PIC used for the immobilization of the enzyme, i.e., the diffusion of the analytes in the PIC.

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SN - 0925-4005

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EP - 63

JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

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T2 - IMCS-7: 7th International Meeting on Chemical Sensors

Y2 - 27 July 1998 through 30 July 1998

ER -

Electrochemical molecular sieving of the polyion complex film for designing highly sensitive biosensor for creatinine

Abstract

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