TY - JOUR
T1 - Electropolymerization molecularly imprinted polymer (E-MIP) SPR sensing of drug molecules
T2 - Pre-polymerization complexed terthiophene and carbazole electroactive monomers
AU - Pernites, Roderick
AU - Ponnapati, Ramakrishna
AU - Felipe, Mary Jane
AU - Advincula, Rigoberto
PY - 2011/1/15
Y1 - 2011/1/15
N2 - A novel chemosensitive ultrathin film with high selectivity was developed for the detection of naproxen, paracetamol, and theophylline using non-covalent electropolymerized molecular imprinted polymers (E-MIP). A series of monofunctional and bifunctional H-bonding terthiophene and carbazole monomers were compared for imprinting these drugs without the use of a separate cross-linker. A key step is the fast and efficient potentiostatic method of washing the template, which facilitated enhanced real-time sensing by surface plasmon resonance (SPR) spectroscopy. Various surface characterizations (contact angle, ellipsometry, XPS, AFM) of the E-MIP film verified the templating and release of the drug from the cross-linked conducting polymer film.
AB - A novel chemosensitive ultrathin film with high selectivity was developed for the detection of naproxen, paracetamol, and theophylline using non-covalent electropolymerized molecular imprinted polymers (E-MIP). A series of monofunctional and bifunctional H-bonding terthiophene and carbazole monomers were compared for imprinting these drugs without the use of a separate cross-linker. A key step is the fast and efficient potentiostatic method of washing the template, which facilitated enhanced real-time sensing by surface plasmon resonance (SPR) spectroscopy. Various surface characterizations (contact angle, ellipsometry, XPS, AFM) of the E-MIP film verified the templating and release of the drug from the cross-linked conducting polymer film.
KW - Electropolymerization
KW - MIP
KW - Naproxen
KW - Paracetamol
KW - Surface plasmon resonance (SPR) sensing
KW - Theophylline
UR - http://www.scopus.com/inward/record.url?scp=78650587946&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650587946&partnerID=8YFLogxK
U2 - 10.1016/j.bios.2010.10.027
DO - 10.1016/j.bios.2010.10.027
M3 - Article
C2 - 21081269
AN - SCOPUS:78650587946
SN - 0956-5663
VL - 26
SP - 2766
EP - 2771
JO - Biosensors and Bioelectronics
JF - Biosensors and Bioelectronics
IS - 5
ER -