Electrospinning of silica nanochannels for single molecule detection

Miao Wang*, Nan Jing, Chin B. Su, Jun Kameoka, Chao Kai Chou, Mien Chie Hung, Kuang An Chang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)


We have fabricated silica nanochannels with inner diameter as small as 20 nm using a scanned coaxial electrospinning and demonstrated their application for single molecule detection. A coaxial jet, with the use of motor oil as the core and silica sol-gel solution as the shell, is extruded through a coaxial source and deposited on the rotating collector as oriented nanofibers. They are then annealed to cross-link silica and eliminate motor oil, thereby forming nanochannels. Subsequently, a fluorescent dye was injected into the individual nanochannels via a capillary force and single molecule detection was performed by monitoring the photon signals from 5-Iodoacetamidofluorescein.

Original languageEnglish
Article number033106
Pages (from-to)1-3
Number of pages3
JournalApplied Physics Letters
Issue number3
Publication statusPublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)


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