Enantioselective divergent approaches to both (-)-platensimycin and (-)-platencin

Sho Hirai, Masahisa Nakada*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)


Enantioselective divergent approaches to (-)-platencin and (-)-platensimycin have been developed. A rationally designed chiral synthetic intermediate, possessing a useful α,β-unsaturated sulfone functionality, which served as a masked ketone as well as a good Michael acceptor, was successfully prepared via the highly enantioselective catalytic asymmetric intramolecular cyclopropanation (CAIMCP) developed in our laboratory.

Original languageEnglish
Pages (from-to)518-530
Number of pages13
Issue number2
Publication statusPublished - 2011 Jan 14


  • Asymmetric catalysis
  • Cyclopropanation
  • Divergent approaches
  • Enantioselective synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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