Enantioselective potential response of a human serum albumin-modified ITO electrode for tryptophan

Mariko Matsunaga; Tsubasa Ueno; Takuya Nakanishi; Tetsuya Osaka

doi:10.1016/j.elecom.2008.09.024

Enantioselective potential response of a human serum albumin-modified ITO electrode for tryptophan

Mariko Matsunaga, Tsubasa Ueno, Takuya Nakanishi, Tetsuya Osaka^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The present study aims at extending the possibility of utilizing bulky molecules such as proteins for fabricating electrochemical chiral sensors using an indium tin oxide (ITO) electrode. Enantioselective potential response of the human serum albumin (HSA)-modified ITO electrode was observed for tryptophan (Trp) when HSA was immobilized on an ITO electrode surface modified with disuccinimidyl suberate (DSS). In this sensing system, the enantioselective interaction between HSA and Trp is detected through the chemically reactive DSS group immobilized on the ITO electrode.

Original language	English
Pages (from-to)	1844-1846
Number of pages	3
Journal	Electrochemistry Communications
Volume	10
Issue number	12
DOIs	https://doi.org/10.1016/j.elecom.2008.09.024
Publication status	Published - 2008 Dec 1

Keywords

Asymmetric synthesis
Chiral sensor
Enantioselective
Field effect transistor
Indium tin oxide
Protein

ASJC Scopus subject areas

Electrochemistry

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10.1016/j.elecom.2008.09.024

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abstract = "The present study aims at extending the possibility of utilizing bulky molecules such as proteins for fabricating electrochemical chiral sensors using an indium tin oxide (ITO) electrode. Enantioselective potential response of the human serum albumin (HSA)-modified ITO electrode was observed for tryptophan (Trp) when HSA was immobilized on an ITO electrode surface modified with disuccinimidyl suberate (DSS). In this sensing system, the enantioselective interaction between HSA and Trp is detected through the chemically reactive DSS group immobilized on the ITO electrode.",

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AU - Matsunaga, Mariko

AU - Ueno, Tsubasa

AU - Nakanishi, Takuya

AU - Osaka, Tetsuya

PY - 2008/12/1

Y1 - 2008/12/1

N2 - The present study aims at extending the possibility of utilizing bulky molecules such as proteins for fabricating electrochemical chiral sensors using an indium tin oxide (ITO) electrode. Enantioselective potential response of the human serum albumin (HSA)-modified ITO electrode was observed for tryptophan (Trp) when HSA was immobilized on an ITO electrode surface modified with disuccinimidyl suberate (DSS). In this sensing system, the enantioselective interaction between HSA and Trp is detected through the chemically reactive DSS group immobilized on the ITO electrode.

AB - The present study aims at extending the possibility of utilizing bulky molecules such as proteins for fabricating electrochemical chiral sensors using an indium tin oxide (ITO) electrode. Enantioselective potential response of the human serum albumin (HSA)-modified ITO electrode was observed for tryptophan (Trp) when HSA was immobilized on an ITO electrode surface modified with disuccinimidyl suberate (DSS). In this sensing system, the enantioselective interaction between HSA and Trp is detected through the chemically reactive DSS group immobilized on the ITO electrode.

KW - Asymmetric synthesis

KW - Chiral sensor

KW - Enantioselective

KW - Field effect transistor

KW - Indium tin oxide

KW - Protein

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JO - Electrochemistry Communications

JF - Electrochemistry Communications

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Enantioselective potential response of a human serum albumin-modified ITO electrode for tryptophan

Abstract

Keywords

ASJC Scopus subject areas

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