Endothelin-1 in the heart during exercise

Seiji Maeda, Takashi Miyauchi, Satoshi Sakai, Tsutomu Kobayashi, Katsutoshi Goto, Yasuro Sugishita, Mitsuo Matsuda*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


In addition to its potent vasocontractile effects, endothelin-1 (ET-1) has potent positive inotropic and chronotropic effects on isolated heart muscles in vitro. However, it is not known whether the production of ET-1 in the heart is altered by exercise. In this study we investigated the production of ET-1 in the heart during exercise. Rats performed treadmill running of 45-min duration. Sedentary rats served as controls. Immediately after exercise, the heart was quickly removed. The peptide level of ET-1 in the heart was measured by a sandwich-enzyme immunoassay. The peptide level of ET-1 in the heart was significantly higher in the exercise group than in the control sedentary group. Therefore, we have demonstrated that production of ET-1 in the heart is increased by exercise. The present study suggests that myocardial ET-1 participates in the modulation of cardiac function during exercise.

Original languageEnglish
Pages (from-to)S392-S394
JournalJournal of Cardiovascular Pharmacology
Issue numberSUPPL. 1
Publication statusPublished - 1998
Externally publishedYes


  • Endothelin-1
  • Exercise
  • Heart

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine


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