Engineered nanomembranes for directing cellular organization toward flexible biodevices

Toshinori Fujie; Samad Ahadian; Hao Liu; Haixin Chang; Serge Ostrovidov; Hongkai Wu; Hojae Bae; Ken Nakajima; Hirokazu Kaji; Ali Khademhosseini

doi:10.1021/nl401237s

Engineered nanomembranes for directing cellular organization toward flexible biodevices

Toshinori Fujie, Samad Ahadian, Hao Liu, Haixin Chang, Serge Ostrovidov, Hongkai Wu, Hojae Bae, Ken Nakajima, Hirokazu Kaji, Ali Khademhosseini^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Abstract

Controlling the cellular microenvironment can be used to direct the cellular organization, thereby improving the function of synthetic tissues in biosensing, biorobotics, and regenerative medicine. In this study, we were inspired by the microstructure and biological properties of the extracellular matrix to develop freestanding ultrathin polymeric films (referred as "nanomembranes") that were flexible, cell adhesive, and had a morphologically tailorable surface. The resulting nanomembranes were exploited as flexible substrates on which cell-adhesive micropatterns were generated to align C2C12 skeletal myoblasts and embedded fibril carbon nanotubes enhanced the cellular elongation and differentiation. Functional nanomembranes with tunable morphology and mechanical properties hold great promise in studying cell-substrate interactions and in fabricating biomimetic constructs toward flexible biodevices.

Original language	English
Pages (from-to)	3185-3192
Number of pages	8
Journal	Nano Letters
Volume	13
Issue number	7
DOIs	https://doi.org/10.1021/nl401237s
Publication status	Published - 2013 Jul 10
Externally published	Yes

Keywords

carbon nanotubes
extracellular matrix
nanomechanical properties
Nanomembranes
skeletal muscle cells

ASJC Scopus subject areas

Condensed Matter Physics
Bioengineering
Chemistry(all)
Materials Science(all)
Mechanical Engineering

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10.1021/nl401237s

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abstract = "Controlling the cellular microenvironment can be used to direct the cellular organization, thereby improving the function of synthetic tissues in biosensing, biorobotics, and regenerative medicine. In this study, we were inspired by the microstructure and biological properties of the extracellular matrix to develop freestanding ultrathin polymeric films (referred as {"}nanomembranes{"}) that were flexible, cell adhesive, and had a morphologically tailorable surface. The resulting nanomembranes were exploited as flexible substrates on which cell-adhesive micropatterns were generated to align C2C12 skeletal myoblasts and embedded fibril carbon nanotubes enhanced the cellular elongation and differentiation. Functional nanomembranes with tunable morphology and mechanical properties hold great promise in studying cell-substrate interactions and in fabricating biomimetic constructs toward flexible biodevices.",

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AU - Fujie, Toshinori

AU - Ahadian, Samad

AU - Liu, Hao

AU - Chang, Haixin

AU - Ostrovidov, Serge

AU - Wu, Hongkai

AU - Bae, Hojae

AU - Nakajima, Ken

AU - Kaji, Hirokazu

AU - Khademhosseini, Ali

PY - 2013/7/10

Y1 - 2013/7/10

N2 - Controlling the cellular microenvironment can be used to direct the cellular organization, thereby improving the function of synthetic tissues in biosensing, biorobotics, and regenerative medicine. In this study, we were inspired by the microstructure and biological properties of the extracellular matrix to develop freestanding ultrathin polymeric films (referred as "nanomembranes") that were flexible, cell adhesive, and had a morphologically tailorable surface. The resulting nanomembranes were exploited as flexible substrates on which cell-adhesive micropatterns were generated to align C2C12 skeletal myoblasts and embedded fibril carbon nanotubes enhanced the cellular elongation and differentiation. Functional nanomembranes with tunable morphology and mechanical properties hold great promise in studying cell-substrate interactions and in fabricating biomimetic constructs toward flexible biodevices.

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KW - carbon nanotubes

KW - extracellular matrix

KW - nanomechanical properties

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Engineered nanomembranes for directing cellular organization toward flexible biodevices

Abstract

Keywords

ASJC Scopus subject areas

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