Engineered nanomembranes for directing cellular organization toward flexible biodevices

Toshinori Fujie, Samad Ahadian, Hao Liu, Haixin Chang, Serge Ostrovidov, Hongkai Wu, Hojae Bae, Ken Nakajima, Hirokazu Kaji, Ali Khademhosseini*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

81 Citations (Scopus)


Controlling the cellular microenvironment can be used to direct the cellular organization, thereby improving the function of synthetic tissues in biosensing, biorobotics, and regenerative medicine. In this study, we were inspired by the microstructure and biological properties of the extracellular matrix to develop freestanding ultrathin polymeric films (referred as "nanomembranes") that were flexible, cell adhesive, and had a morphologically tailorable surface. The resulting nanomembranes were exploited as flexible substrates on which cell-adhesive micropatterns were generated to align C2C12 skeletal myoblasts and embedded fibril carbon nanotubes enhanced the cellular elongation and differentiation. Functional nanomembranes with tunable morphology and mechanical properties hold great promise in studying cell-substrate interactions and in fabricating biomimetic constructs toward flexible biodevices.

Original languageEnglish
Pages (from-to)3185-3192
Number of pages8
JournalNano Letters
Issue number7
Publication statusPublished - 2013 Jul 10
Externally publishedYes


  • carbon nanotubes
  • extracellular matrix
  • nanomechanical properties
  • Nanomembranes
  • skeletal muscle cells

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering


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