Enhancement of hemostatic ability of dodecapeptide-conjugated phospholipid vesicles by encapsulation of a platelet aggregation-induced factor

Yosuke Okamura; Ippei Maekawa; Makoto Handa; Yasuo Ikeda; Shinji Takeoka

Enhancement of hemostatic ability of dodecapeptide-conjugated phospholipid vesicles by encapsulation of a platelet aggregation-induced factor

Yosuke Okamura^*, Ippei Maekawa, Makoto Handa, Yasuo Ikeda, Shinji Takeoka

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

We conjugated dodecapeptide (H12); a part of the amino acid sequence of fibrinogen, to the terminal of a part of polyethylenglycol chains which modified the surface of the phospholipids vesicles. In this report, we further encapsulated ADP; platelet aggregation-induced factor in the vesicle to enhance the hemostasis of thrombocytopenic rats.

Original language	English
Number of pages	1
Publication status	Published - 2006 Oct 19
Event	55th SPSJ Annual Meeting - Nagoya, Japan Duration: 2006 May 24 → 2006 May 26

Conference

Conference	55th SPSJ Annual Meeting
Country/Territory	Japan
City	Nagoya
Period	06/5/24 → 06/5/26

Keywords

Dodecapeptide (H12)
Haemostatic effect.
Phospholipid vesicles
Platelet substitutes
Release property

ASJC Scopus subject areas

Engineering(all)

Cite this

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title = "Enhancement of hemostatic ability of dodecapeptide-conjugated phospholipid vesicles by encapsulation of a platelet aggregation-induced factor",

abstract = "We conjugated dodecapeptide (H12); a part of the amino acid sequence of fibrinogen, to the terminal of a part of polyethylenglycol chains which modified the surface of the phospholipids vesicles. In this report, we further encapsulated ADP; platelet aggregation-induced factor in the vesicle to enhance the hemostasis of thrombocytopenic rats.",

keywords = "Dodecapeptide (H12), Haemostatic effect., Phospholipid vesicles, Platelet substitutes, Release property",

author = "Yosuke Okamura and Ippei Maekawa and Makoto Handa and Yasuo Ikeda and Shinji Takeoka",

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day = "19",

language = "English",

note = "55th SPSJ Annual Meeting ; Conference date: 24-05-2006 Through 26-05-2006",

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T1 - Enhancement of hemostatic ability of dodecapeptide-conjugated phospholipid vesicles by encapsulation of a platelet aggregation-induced factor

AU - Okamura, Yosuke

AU - Maekawa, Ippei

AU - Handa, Makoto

AU - Ikeda, Yasuo

AU - Takeoka, Shinji

PY - 2006/10/19

Y1 - 2006/10/19

N2 - We conjugated dodecapeptide (H12); a part of the amino acid sequence of fibrinogen, to the terminal of a part of polyethylenglycol chains which modified the surface of the phospholipids vesicles. In this report, we further encapsulated ADP; platelet aggregation-induced factor in the vesicle to enhance the hemostasis of thrombocytopenic rats.

AB - We conjugated dodecapeptide (H12); a part of the amino acid sequence of fibrinogen, to the terminal of a part of polyethylenglycol chains which modified the surface of the phospholipids vesicles. In this report, we further encapsulated ADP; platelet aggregation-induced factor in the vesicle to enhance the hemostasis of thrombocytopenic rats.

KW - Dodecapeptide (H12)

KW - Haemostatic effect.

KW - Phospholipid vesicles

KW - Platelet substitutes

KW - Release property

UR - http://www.scopus.com/inward/record.url?scp=33749824119&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749824119&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33749824119

T2 - 55th SPSJ Annual Meeting

Y2 - 24 May 2006 through 26 May 2006

ER -

Enhancement of hemostatic ability of dodecapeptide-conjugated phospholipid vesicles by encapsulation of a platelet aggregation-induced factor

Abstract

Conference

Keywords

ASJC Scopus subject areas

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