TY - JOUR
T1 - Environmental estrogens and reproductive biology in amphibians
AU - Mosconi, G.
AU - Carnevali, O.
AU - Franzoni, M. F.
AU - Cottone, E.
AU - Lutz, I.
AU - Kloas, W.
AU - Yamamoto, K.
AU - Kikuyama, S.
AU - Polzonetti-Magni, A. M.
PY - 2002
Y1 - 2002
N2 - In this paper, the effects of an estrogenic compound, 4-nonyl-phenol (NP), on the amphibians Rana esculenta and Triturus carnifex are described together with those on sexual differentiation in Xenopus laevis. NP increased plasma vitellogenin in male frogs and newts in a dose-related manner; moreover, inhibitory effects on gonadotropin and prolactin (PRL) secretion by pituitary were found together with an elevation of plasma androgens. NP treatment also caused a remarkable increase in number of prolactin-immunolabeled cells, suggesting that xenoestrogen might induce, at least in the newt pituitary, a PRL accumulation possibly due to a reduction of the hormone release. In addition, both NP and bisphenol A caused feminization by increasing the percentage of female phenotypes in X. laevis, and the in vivo effects were more pronounced than those of estradiol-17β.
AB - In this paper, the effects of an estrogenic compound, 4-nonyl-phenol (NP), on the amphibians Rana esculenta and Triturus carnifex are described together with those on sexual differentiation in Xenopus laevis. NP increased plasma vitellogenin in male frogs and newts in a dose-related manner; moreover, inhibitory effects on gonadotropin and prolactin (PRL) secretion by pituitary were found together with an elevation of plasma androgens. NP treatment also caused a remarkable increase in number of prolactin-immunolabeled cells, suggesting that xenoestrogen might induce, at least in the newt pituitary, a PRL accumulation possibly due to a reduction of the hormone release. In addition, both NP and bisphenol A caused feminization by increasing the percentage of female phenotypes in X. laevis, and the in vivo effects were more pronounced than those of estradiol-17β.
KW - Amphibians
KW - Reproduction
KW - Xenoestrogens
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U2 - 10.1006/gcen.2002.7781
DO - 10.1006/gcen.2002.7781
M3 - Article
C2 - 12030767
AN - SCOPUS:0036096361
SN - 0016-6480
VL - 126
SP - 125
EP - 129
JO - General and Comparative Endocrinology
JF - General and Comparative Endocrinology
IS - 2
ER -