@article{92af3aec309145b18a43d4a4581a5a54,
title = "Enzyme inhibitors, synthesis and approach to mechanism",
abstract = "Synthetic approach toward channel protein inhibitors (tetrodotoxin, ciguatoxin) and protein phosphatase inhibitors (tautomycin) is discussed with special reference to the stereochemical control.",
author = "M. Isobe and K. Tsuboi and S. Hosokawa and M. Bamba and K. Kira and S. Shibuya and Ohtani, {I. I.} and T. Nishikawa and Y. Ichikawa",
note = "Funding Information: The cationic intermediate allowed the conversion of the cis-olefin in 41 into the corresponding trans-open chain molecule (42) which was finally cyclized and decomplexed to the 2S,5S diol44. Similarly 2R,5S was synthesized. These syntheses accelerate the synthesis of other portion of ciguatoxin.19 Acknowledgment Authors are indebted to the Grant-in-aid for Scientific Research from Ministry of Education, Science and Culture.",
year = "1997",
month = mar,
doi = "10.1351/pac199769030401",
language = "English",
volume = "69",
pages = "401--406",
journal = "Pure and Applied Chemistry",
issn = "0033-4545",
publisher = "IUPAC Secretariat",
number = "3",
}