Abstract
Erythropoietin is the primary and physiological regulator of erythropoiesis, that is, the production of red blood cells. It is a glycoprotein produced predominantly in the fetal liver and the adult kidney. It circulates into the adult bone marrow, and binds to its dimerizing receptor on the surface of erythroid progenitor cells to promote cell survival, proliferation, and differentiation. Other nonhematopoietic roles of neuroprotection, cardioprotection, renoprotection, and wound healing have been reported.
Original language | English |
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Title of host publication | Handbook of Hormones |
Subtitle of host publication | Comparative Endocrinology for Basic and Clinical Research |
Publisher | Elsevier |
Pages | 457-460 |
Number of pages | 4 |
ISBN (Electronic) | 9780128206492 |
DOIs | |
Publication status | Published - 2021 Jan 1 |
Keywords
- Cytokine
- Erythrocytes
- Erythroids
- Erythropoiesis
- Hematopoiesis
- Hematopoietic growth factor
- Red blood cells
ASJC Scopus subject areas
- Medicine(all)