Estimation of Kinetics for Batch Cooling Crystallization by Focused-Beam Reflectance Measurements

Joi Unno*, Hiroki Kawase, Reiya Kaneshige, Izumi Hirasawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Numerical simulation of the seeded batch cooling crystallization process of active pharmaceutical ingredients was performed. Crystal size distribution was observed by focused-beam reflectance measurements and concentration by simultaneous Fourier transform infrared spectroscopy. First, kinetic parameters were estimated. Nucleation rate coefficient and order were estimated from the linear regression equation between cooling rate and metastable zone width. The remaining parameters were estimated from the evaluation function. Then, the numerical simulation was performed by utilizing the method of moments. Finally, observed data were compared with simulated data. The simulated values of mean mass size corresponded reasonably with the observed ones.

Original languageEnglish
Pages (from-to)1428-1434
Number of pages7
JournalChemical Engineering and Technology
Issue number7
Publication statusPublished - 2019 Jul


  • Active pharmaceutical ingredients
  • Crystal size distribution
  • Crystallization
  • Focused-beam reflectance measurements
  • Simulation

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering
  • Industrial and Manufacturing Engineering


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