Estradiol-tethered micropatterned surfaces for the study of estrogenic non-genomic pathways

B. Qi; Y. Shimizu; J. Nakanishi; F. M. Winnik

doi:10.1039/c6cc03899a

Estradiol-tethered micropatterned surfaces for the study of estrogenic non-genomic pathways

B. Qi, Y. Shimizu, J. Nakanishi^*, F. M. Winnik

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Besides its well-known hormonal effects initiated in the nucleus, estradiol (E2) also activates non-nuclear pathways through interactions with receptors located on the cell plasma membrane. Micropatterned substrates consisting of gold dots bearing tethered E2 distributed on a cell-adhesive substrate were prepared and shown to trigger specifically E2 non-genomic effects in cells grown on the substrates.

Original language	English
Pages (from-to)	10056-10059
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	65
DOIs	https://doi.org/10.1039/c6cc03899a
Publication status	Published - 2016
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Chemistry(all)
Catalysis

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abstract = "Besides its well-known hormonal effects initiated in the nucleus, estradiol (E2) also activates non-nuclear pathways through interactions with receptors located on the cell plasma membrane. Micropatterned substrates consisting of gold dots bearing tethered E2 distributed on a cell-adhesive substrate were prepared and shown to trigger specifically E2 non-genomic effects in cells grown on the substrates.",

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AU - Qi, B.

AU - Shimizu, Y.

AU - Nakanishi, J.

AU - Winnik, F. M.

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Y1 - 2016

N2 - Besides its well-known hormonal effects initiated in the nucleus, estradiol (E2) also activates non-nuclear pathways through interactions with receptors located on the cell plasma membrane. Micropatterned substrates consisting of gold dots bearing tethered E2 distributed on a cell-adhesive substrate were prepared and shown to trigger specifically E2 non-genomic effects in cells grown on the substrates.

AB - Besides its well-known hormonal effects initiated in the nucleus, estradiol (E2) also activates non-nuclear pathways through interactions with receptors located on the cell plasma membrane. Micropatterned substrates consisting of gold dots bearing tethered E2 distributed on a cell-adhesive substrate were prepared and shown to trigger specifically E2 non-genomic effects in cells grown on the substrates.

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Estradiol-tethered micropatterned surfaces for the study of estrogenic non-genomic pathways

Abstract

ASJC Scopus subject areas

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