Evaluation of circadian clock model based on orbital stability

Takamich Hinohara*, Kenko Uchida

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference contribution


    The interactions among the components of biological systems, which are DNA, RNA and proteins, create specific cell functions. Recently, many works try to understand mechanism of the interactions from dynamical systems viewpoints, and for this problem, concepts and results in control engineering are expected to play significant role. However, the biological systems are generally nonlinear and complex, and are difficult objects of analysis and synthesis. In this paper, we propose an evaluation method, which is based on orbital stability analysis, of identifying important parts of nonlinear systems that have periodic orbits such as circadian rhythms or cell cycle control, and apply the method to a circadian rhythm model for Drosophila proposed by Leloup and Goldbeter (1998).

    Original languageEnglish
    Title of host publicationProceedings of the SICE Annual Conference
    Number of pages5
    Publication statusPublished - 2007
    EventSICE(Society of Instrument and Control Engineers)Annual Conference, SICE 2007 - Takamatsu
    Duration: 2007 Sept 172007 Sept 20


    OtherSICE(Society of Instrument and Control Engineers)Annual Conference, SICE 2007


    • Circadian rhythm
    • Modeling
    • Orbital stability

    ASJC Scopus subject areas

    • Engineering(all)


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