Exercise and hormesis: Shaping the dose-response curve

Zsolt Radak*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)


Physical inactivity is a major contributor to the development of lifestyle-related diseases, including cardiovascular diseases (Lee et al. 2013; Oppewal et al. 2013), certain tumors, type 2 diabetes (Kasuga et al. 2013), osteoporosis (Janssen 2012), and even neurodegenerative diseases (Radak et al. 2010; Janssen 2012). This could be partly because the development of the genome at the genesis of humans was associated with a physically active lifestyle. It has been suggested that Stone Age man used 4000 kcal for physical activity on a daily basis (Radak et al. 2013c). Adaptive changes on the DNA sequence are very slow. Therefore, it is not surprising that physical inactivity is a risk factor for a wide range of diseases.

Original languageEnglish
Title of host publicationHormesis in Health and Disease
PublisherCRC Press
Number of pages8
ISBN (Electronic)9781482205466
ISBN (Print)9781482205459
Publication statusPublished - 2014 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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