TY - CHAP
T1 - F 1-ATPase
T2 - A prototypical rotary molecular motor
AU - Kinosita, Kazuhiko
PY - 2012
Y1 - 2012
N2 - F 1-ATPase, the soluble portion of ATP synthase, has been shown to be a rotary molecular motor in which the central γ subunit rotates inside the cylinder made of α 3β 3 subunits. The rotation is powered by ATP hydrolysis in three catalytic sites, and reverse rotation of the γ subunit by an external force leads to ATP synthesis in the catalytic sites. Here I look back how our lab became involved in the study of this marvelous rotary machine, and discuss some aspects of its rotary mechanism while confessing we are far from understanding. This article is a very personal essay, not a scientific review, for this otherwise viral machines book.
AB - F 1-ATPase, the soluble portion of ATP synthase, has been shown to be a rotary molecular motor in which the central γ subunit rotates inside the cylinder made of α 3β 3 subunits. The rotation is powered by ATP hydrolysis in three catalytic sites, and reverse rotation of the γ subunit by an external force leads to ATP synthesis in the catalytic sites. Here I look back how our lab became involved in the study of this marvelous rotary machine, and discuss some aspects of its rotary mechanism while confessing we are far from understanding. This article is a very personal essay, not a scientific review, for this otherwise viral machines book.
UR - http://www.scopus.com/inward/record.url?scp=84858176595&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858176595&partnerID=8YFLogxK
U2 - 10.1007/978-1-4614-0980-9_2
DO - 10.1007/978-1-4614-0980-9_2
M3 - Chapter
C2 - 22297508
AN - SCOPUS:84858176595
SN - 9781461409793
VL - 726
T3 - Advances in Experimental Medicine and Biology
SP - 5
EP - 16
BT - Advances in Experimental Medicine and Biology
ER -