F-substituted carbonate apatite for promoting bone formation

Yu Sogo*, Daiki Yokoyama, Atsuo Ito, Atsushi Yamazaki, Racquel Z. LeGeros

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Fluoride (F)-substituted type-B carbonate-containing hydroxyapatites (CHAPs) were prepared as bone substitutes with a F-releasing ability. The F - contents in the F-substituted CHAPs were 16-22 times larger than that in normal adult human bones. The carbonate contents in the F-substituted CHAPs corresponded to that in human bones. The F-substituted CHAPs released F- in an acetic acid - sodium acetate buffer at pH 4.9; within only 3 h, the F- concentration in the buffer increased to more than 63.9 μg L-1, which was 1.5- 8.9 times higher than that in a body fluid of normal adult humans. Although the F- concentration rapidly decreased probably due to the precipitation of a certain phase containing F-, the F-substituted CHAPs exhibited the ability to increase the F- concentration in a body fluid by bone resorption. Therefore, it is expected that the F-substituted CHAPs will be feasible as a F-releasing material for promoting bone formation.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalKey Engineering Materials
Volume309-311 I
Publication statusPublished - 2006 Jan 1


  • Bone substitute
  • Carbonate-containing hydroxyapatite
  • Fluoride
  • Release property

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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