TY - JOUR
T1 - Fabrication of free-standing nanoparticle-fused nanosheets and their hetero-modification using sacrificial film
AU - Okamura, Yosuke
AU - Utsunomiya, Saori
AU - Suzuki, Hidenori
AU - Niwa, Daisuke
AU - Osaka, Tetsuya
AU - Takeoka, Shinji
N1 - Funding Information:
This work was supported by 21COE “Practical Nano-Chemistry”, “Consolidated Research Institute for Advanced Science and Medical Care” from MEXT, Japan, and Shorai Foundation for Science and Technology (S.T.). Y.O. was the recipient of a Research Fellowships from the Japan Health Science Foundation.
PY - 2008/4/1
Y1 - 2008/4/1
N2 - Sheet-shaped carriers, having obverse and reverse surfaces and thus a large contact area as a targeting site, have several advantages over spherical-shaped carriers, which have an extremely small contact area. Herein is proposed a novel method for the preparation of free-standing nanoparticle-fused nanosheets having uniform micrometer shape, nanometer thickness and heterogenous surfaces, using a water-soluble sacrificial film. This was achieved by combination of four processes: (1) specific adsorption of latex beads at pH 5.0 and a concentration of 1.0 × 1011 mL-1 onto a patterned dodecyltrimethoxysilane self-assembled monolayer (DTS-SAM) region by a conventional dry patterning process, (2) fabrication of the latex bead-sheet via thermal-fusion at 110 °C for 60 s, (3) preparation of the free-standing nanosheet by detachment from the DTS-SAM, and (4) hetero-modification of the resulting nanosheet using a water-soluble poly(acrylic acid) as a sacrificial supporting film. Thus, this sheet-shaped carrier having hetero-surfaces can be regarded as a new material for delivery of drugs, hemostatic reagents and as wound dressings for burn injury, etc.
AB - Sheet-shaped carriers, having obverse and reverse surfaces and thus a large contact area as a targeting site, have several advantages over spherical-shaped carriers, which have an extremely small contact area. Herein is proposed a novel method for the preparation of free-standing nanoparticle-fused nanosheets having uniform micrometer shape, nanometer thickness and heterogenous surfaces, using a water-soluble sacrificial film. This was achieved by combination of four processes: (1) specific adsorption of latex beads at pH 5.0 and a concentration of 1.0 × 1011 mL-1 onto a patterned dodecyltrimethoxysilane self-assembled monolayer (DTS-SAM) region by a conventional dry patterning process, (2) fabrication of the latex bead-sheet via thermal-fusion at 110 °C for 60 s, (3) preparation of the free-standing nanosheet by detachment from the DTS-SAM, and (4) hetero-modification of the resulting nanosheet using a water-soluble poly(acrylic acid) as a sacrificial supporting film. Thus, this sheet-shaped carrier having hetero-surfaces can be regarded as a new material for delivery of drugs, hemostatic reagents and as wound dressings for burn injury, etc.
KW - Free-standing
KW - Hetero-modification
KW - Nanosheet
KW - Sacrificial film
KW - Thermal fusion
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U2 - 10.1016/j.colsurfa.2007.12.049
DO - 10.1016/j.colsurfa.2007.12.049
M3 - Article
AN - SCOPUS:40649099533
SN - 0927-7757
VL - 318
SP - 184
EP - 190
JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects
JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects
IS - 1-3
ER -