Fabrication of lipid tubules with embedded quantum dots by membrane tubulation protein

Masayoshi Tanaka; Kevin Critchley; Tadashi Matsunaga; Stephen D. Evans; Sarah S. Staniland

doi:10.1002/smll.201102446

Fabrication of lipid tubules with embedded quantum dots by membrane tubulation protein

Masayoshi Tanaka^*, Kevin Critchley, Tadashi Matsunaga, Stephen D. Evans, Sarah S. Staniland

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The first one-dimensional (1D) assembly of low-toxicity CuInS ₂/ZnS quantum dots (QDs) embedded in lipid nanotubules, formed from liposomes using the Amphiphysin-BAR (Bin-Amphiphysin-Rvs domain of human amphiphysin) protein to elongate the structure, is reported. The QD-containing lipid nanotubules display a high aspect ratio of ≈500:1 (≈40 nm diameter and 20 μm length) and are stable for more than 20 h. Furthermore, this methodology is extended to the assembly of various nanoparticle species within 1D lipid nanotubules, and includes materials such as CdSe and Au. Encapsulation within the hydrophobic core of the bilayer makes these materials highly biocompatible. The developed methodology and materials with these unique characteristics could be useful for various applications in nanobiotechnology and nanomedicine.

Original language	English
Pages (from-to)	1590-1595
Number of pages	6
Journal	Small
Volume	8
Issue number	10
DOIs	https://doi.org/10.1002/smll.201102446
Publication status	Published - 2012 May 21
Externally published	Yes

Keywords

biocompatible materials
encapsulation
lipid tubules
nanoparticles
quantum dots

ASJC Scopus subject areas

Biomaterials
Engineering (miscellaneous)
Biotechnology
Medicine(all)

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10.1002/smll.201102446

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title = "Fabrication of lipid tubules with embedded quantum dots by membrane tubulation protein",

abstract = "The first one-dimensional (1D) assembly of low-toxicity CuInS 2/ZnS quantum dots (QDs) embedded in lipid nanotubules, formed from liposomes using the Amphiphysin-BAR (Bin-Amphiphysin-Rvs domain of human amphiphysin) protein to elongate the structure, is reported. The QD-containing lipid nanotubules display a high aspect ratio of ≈500:1 (≈40 nm diameter and 20 μm length) and are stable for more than 20 h. Furthermore, this methodology is extended to the assembly of various nanoparticle species within 1D lipid nanotubules, and includes materials such as CdSe and Au. Encapsulation within the hydrophobic core of the bilayer makes these materials highly biocompatible. The developed methodology and materials with these unique characteristics could be useful for various applications in nanobiotechnology and nanomedicine.",

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AU - Tanaka, Masayoshi

AU - Critchley, Kevin

AU - Matsunaga, Tadashi

AU - Evans, Stephen D.

AU - Staniland, Sarah S.

PY - 2012/5/21

Y1 - 2012/5/21

N2 - The first one-dimensional (1D) assembly of low-toxicity CuInS 2/ZnS quantum dots (QDs) embedded in lipid nanotubules, formed from liposomes using the Amphiphysin-BAR (Bin-Amphiphysin-Rvs domain of human amphiphysin) protein to elongate the structure, is reported. The QD-containing lipid nanotubules display a high aspect ratio of ≈500:1 (≈40 nm diameter and 20 μm length) and are stable for more than 20 h. Furthermore, this methodology is extended to the assembly of various nanoparticle species within 1D lipid nanotubules, and includes materials such as CdSe and Au. Encapsulation within the hydrophobic core of the bilayer makes these materials highly biocompatible. The developed methodology and materials with these unique characteristics could be useful for various applications in nanobiotechnology and nanomedicine.

AB - The first one-dimensional (1D) assembly of low-toxicity CuInS 2/ZnS quantum dots (QDs) embedded in lipid nanotubules, formed from liposomes using the Amphiphysin-BAR (Bin-Amphiphysin-Rvs domain of human amphiphysin) protein to elongate the structure, is reported. The QD-containing lipid nanotubules display a high aspect ratio of ≈500:1 (≈40 nm diameter and 20 μm length) and are stable for more than 20 h. Furthermore, this methodology is extended to the assembly of various nanoparticle species within 1D lipid nanotubules, and includes materials such as CdSe and Au. Encapsulation within the hydrophobic core of the bilayer makes these materials highly biocompatible. The developed methodology and materials with these unique characteristics could be useful for various applications in nanobiotechnology and nanomedicine.

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KW - encapsulation

KW - lipid tubules

KW - nanoparticles

KW - quantum dots

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ER -

Fabrication of lipid tubules with embedded quantum dots by membrane tubulation protein

Abstract

Keywords

ASJC Scopus subject areas

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