TY - JOUR
T1 - Fabrication of microneedle using poly lactic acid sheets by thermal nanoimprint
AU - Terashima, Shingo
AU - Tatsukawa, Chikako
AU - Suzuki, Masato
AU - Takahashi, Tomokazu
AU - Aoyagi, Seiji
N1 - Funding Information:
This work was supported by KAKENHI ( 18H01415 ) from JSPS (Japanese Society for the Promotion of Science). This work was supported in part by a Strategic Research Foundation at Private Universities “Creation of 3D nano-micro structures and its application to biomimetics and medicine” from MEXT (Ministry of Education, Culture, Sports, Science, and Technology, Japan), 2015–2019.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/9
Y1 - 2019/9
N2 - A biodegradable PLA (poly-lactic acid) microneedle having high aspect ratio of over 10, e.g., 100 μm in diameter and 1,000 μm (1 mm) in length, was successfully fabricated using thermal nanoimprint method first in the world. First, optimal conditions for fabricating a conical shape, which is assuming a microneedle tip, were preliminarily investigated. Both in vacuum and under atmospheric pressure, pressure of 20 MPa and temperature of 160 °C were necessary. Next, fabrication of a long microneedle was investigated. As compared to the conical shape, higher pressure of 25 MPa and higher temperature of 166 °C were required. By adjusting the releasing temperature around 98 °C, fabrication of a long microneedle having a smooth surface and no deformation, e.g., no bending, was successfully achieved. It was confirmed that the needle surely can puncture the skin and blood vessel of a mouse.
AB - A biodegradable PLA (poly-lactic acid) microneedle having high aspect ratio of over 10, e.g., 100 μm in diameter and 1,000 μm (1 mm) in length, was successfully fabricated using thermal nanoimprint method first in the world. First, optimal conditions for fabricating a conical shape, which is assuming a microneedle tip, were preliminarily investigated. Both in vacuum and under atmospheric pressure, pressure of 20 MPa and temperature of 160 °C were necessary. Next, fabrication of a long microneedle was investigated. As compared to the conical shape, higher pressure of 25 MPa and higher temperature of 166 °C were required. By adjusting the releasing temperature around 98 °C, fabrication of a long microneedle having a smooth surface and no deformation, e.g., no bending, was successfully achieved. It was confirmed that the needle surely can puncture the skin and blood vessel of a mouse.
KW - Biodegradable material
KW - Microneedle
KW - Poly lactic acid (PLA)
KW - Thermal nanoimprint
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U2 - 10.1016/j.precisioneng.2019.05.015
DO - 10.1016/j.precisioneng.2019.05.015
M3 - Article
AN - SCOPUS:85067281980
SN - 0141-6359
VL - 59
SP - 110
EP - 119
JO - Precision Engineering
JF - Precision Engineering
ER -