Fabrication, Properties, and Biomedical Applications of Nanosheets

Toshinori Fujie*, Yosuke Okamura, Shinji Takeoka

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Citations (Scopus)


Nanosheets, ultrathin sheet-shaped materials, have several advantages in the biomedical field; a large contact area in the biointerface, noncovalent adhesion, small amount ofmaterial required, and dual surfaces for heterofunctionalization. In terms of a drug-delivery vehicle, the sheet-shaped carriers perform unique dynamic functions over spherically shaped carriers. For surgical dressing, the sheet-shaped materials can densely overlap the tissue defect site without the need for chemical adhesive reagents. In this review, we propose a methodology for the preparation of freestanding, ultrathin nanosheets with a huge aspect ratio and heterosurfaces, fabricated through molecular assembly. In their practical biomedical applications, the micrometer-sized nanosheet was constructed by exploiting a micropatterned substrate with a precisely controlled size, applicable for injectable sheet-shaped drug carriers, whereas the giant nanosheets, with an aspect ratio of >106, can act as novel biomaterials for surgical dressing in the next generation of minimally invasive treatments.

Original languageEnglish
Title of host publicationFunctional Polymer Films
Number of pages25
ISBN (Print)9783527321902
Publication statusPublished - 2011 Jun 7


  • Biomedical applications
  • Drug-delivery vehicle
  • Heterofunctionalization
  • Nanoadhesive plasters
  • Nanosheets
  • Platelet substitutes

ASJC Scopus subject areas

  • General Physics and Astronomy
  • General Materials Science


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