Facilitatory effects of somatostatin on reduced uptake of 2-deoxyglucose in cerebral cortical and hippocampal slices from aged rats

Shibata Shigenobu Shibata; Tanaka Takeshi Tanaka; Watanabe Shigenori Watanabe

doi:10.1016/0922-4106(94)90096-5

Facilitatory effects of somatostatin on reduced uptake of 2-deoxyglucose in cerebral cortical and hippocampal slices from aged rats

Shibata Shigenobu Shibata^*, Tanaka Takeshi Tanaka, Watanabe Shigenori Watanabe

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of the present study was to determine whether or not the reduction of 2-deoxyglucose uptake by the cerebral cortical slices in aged rats (22-23 months old) was attenuated by somatostatin or carbachol. In 8-week-old rats, somatostatin and carbachol produced concentration-dependent increases in 2-deoxyglucose uptake. 2-Deoxyglucose uptake of the cortical slices in 2-23-month-old rats was significantly facilitated by treatment with 0.1-1 ωM somatostatin or 1-100 ωM carbachol. Metabolic responses to somatostatin or carbachol were quite similar in young and aged rats. The present results demonstrated that 2-deoxyglucose uptake by the cerebral cortex was facilitated by somatostatin and carbachol in both young and old rats.

Original language	English
Pages (from-to)	269-272
Number of pages	4
Journal	European Journal of Pharmacology: Molecular Pharmacology
Volume	269
Issue number	2
DOIs	https://doi.org/10.1016/0922-4106(94)90096-5
Publication status	Published - 1994 Oct 14
Externally published	Yes

Keywords

2-Deoxyglucose
Aging
Brain slice
Carbachol
Cerebral cortex
Somatostatin

ASJC Scopus subject areas

Pharmacology

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10.1016/0922-4106(94)90096-5

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Facilitatory effects of somatostatin on reduced uptake of 2-deoxyglucose in cerebral cortical and hippocampal slices from aged rats. / Shigenobu Shibata, Shibata; Takeshi Tanaka, Tanaka; Shigenori Watanabe, Watanabe.
In: European Journal of Pharmacology: Molecular Pharmacology, Vol. 269, No. 2, 14.10.1994, p. 269-272.

Research output: Contribution to journal › Article › peer-review

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title = "Facilitatory effects of somatostatin on reduced uptake of 2-deoxyglucose in cerebral cortical and hippocampal slices from aged rats",

abstract = "The aim of the present study was to determine whether or not the reduction of 2-deoxyglucose uptake by the cerebral cortical slices in aged rats (22-23 months old) was attenuated by somatostatin or carbachol. In 8-week-old rats, somatostatin and carbachol produced concentration-dependent increases in 2-deoxyglucose uptake. 2-Deoxyglucose uptake of the cortical slices in 2-23-month-old rats was significantly facilitated by treatment with 0.1-1 ωM somatostatin or 1-100 ωM carbachol. Metabolic responses to somatostatin or carbachol were quite similar in young and aged rats. The present results demonstrated that 2-deoxyglucose uptake by the cerebral cortex was facilitated by somatostatin and carbachol in both young and old rats.",

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N2 - The aim of the present study was to determine whether or not the reduction of 2-deoxyglucose uptake by the cerebral cortical slices in aged rats (22-23 months old) was attenuated by somatostatin or carbachol. In 8-week-old rats, somatostatin and carbachol produced concentration-dependent increases in 2-deoxyglucose uptake. 2-Deoxyglucose uptake of the cortical slices in 2-23-month-old rats was significantly facilitated by treatment with 0.1-1 ωM somatostatin or 1-100 ωM carbachol. Metabolic responses to somatostatin or carbachol were quite similar in young and aged rats. The present results demonstrated that 2-deoxyglucose uptake by the cerebral cortex was facilitated by somatostatin and carbachol in both young and old rats.

AB - The aim of the present study was to determine whether or not the reduction of 2-deoxyglucose uptake by the cerebral cortical slices in aged rats (22-23 months old) was attenuated by somatostatin or carbachol. In 8-week-old rats, somatostatin and carbachol produced concentration-dependent increases in 2-deoxyglucose uptake. 2-Deoxyglucose uptake of the cortical slices in 2-23-month-old rats was significantly facilitated by treatment with 0.1-1 ωM somatostatin or 1-100 ωM carbachol. Metabolic responses to somatostatin or carbachol were quite similar in young and aged rats. The present results demonstrated that 2-deoxyglucose uptake by the cerebral cortex was facilitated by somatostatin and carbachol in both young and old rats.

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KW - Brain slice

KW - Carbachol

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Facilitatory effects of somatostatin on reduced uptake of 2-deoxyglucose in cerebral cortical and hippocampal slices from aged rats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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