TY - JOUR
T1 - Fish oil accelerates diet-induced entrainment of the mouse peripheral clock via GPR120
AU - Furutani, Akiko
AU - Ikeda, Yuko
AU - Itokawa, Misa
AU - Nagahama, Hiroki
AU - Ohtsu, Teiji
AU - Furutani, Naoki
AU - Kamagata, Mayo
AU - Yang, Zhi Hong
AU - Hirasawa, Akira
AU - Tahara, Yu
AU - Shibata, Shigenobu
N1 - Funding Information:
This work was partially supported by the Council for Science, Technology and Innovation, SIP, “Technologies for creating next-generation agriculture, forestry and fisheries” (funding agency: Bio-oriented Technology Research Advancement Institution, NARO) (S.S.), and by a Grant-in-Aid for Scientific Research (S) (26220201) from the Ministry of Education, Culture, Sports, Science and Technology of Japan (S.S.). This work was also partially supported by Nippon Suisan Kaisha in the form of salary for author Z-H Yang. Dr. Z-H Yang helped to examine the fatty acid analysis in the fish oil.
Publisher Copyright:
© 2015 Furutani et al.
PY - 2015/7/10
Y1 - 2015/7/10
N2 - The circadian peripheral clock is entrained by restricted feeding (RF) at a fixed time of day, and insulin secretion regulates RF-induced entrainment of the peripheral clock in mice. Thus, carbohydrate-rich food may be ideal for facilitating RF-induced entrainment, although the role of dietary oils in insulin secretion and RF-induced entrainment has not been described. The soybean oil component of standard mouse chow was substituted with fish or soybean oil containing docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA). Tuna oil (high DHA/EPA), menhaden oil (standard), and DHA/EPA dissolved in soybean oil increased insulin secretion and facilitated RF-induced phase shifts of the liver clock as represented by the bioluminescence rhythms of PER2::LUCIFERASE knock-in mice. In this model, insulin depletion blocked the effect of tuna oil and fish oil had no effect on mice deficient for GPR120, a polyunsaturated fatty acid receptor. These results suggest food containing fish oil or DHA/EPA is ideal for adjusting the peripheral clock.
AB - The circadian peripheral clock is entrained by restricted feeding (RF) at a fixed time of day, and insulin secretion regulates RF-induced entrainment of the peripheral clock in mice. Thus, carbohydrate-rich food may be ideal for facilitating RF-induced entrainment, although the role of dietary oils in insulin secretion and RF-induced entrainment has not been described. The soybean oil component of standard mouse chow was substituted with fish or soybean oil containing docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA). Tuna oil (high DHA/EPA), menhaden oil (standard), and DHA/EPA dissolved in soybean oil increased insulin secretion and facilitated RF-induced phase shifts of the liver clock as represented by the bioluminescence rhythms of PER2::LUCIFERASE knock-in mice. In this model, insulin depletion blocked the effect of tuna oil and fish oil had no effect on mice deficient for GPR120, a polyunsaturated fatty acid receptor. These results suggest food containing fish oil or DHA/EPA is ideal for adjusting the peripheral clock.
UR - http://www.scopus.com/inward/record.url?scp=84941334292&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941334292&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0132472
DO - 10.1371/journal.pone.0132472
M3 - Article
C2 - 26161796
AN - SCOPUS:84941334292
SN - 1932-6203
VL - 10
JO - PloS one
JF - PloS one
IS - 7
M1 - e0132472
ER -