Fish oil accelerates diet-induced entrainment of the mouse peripheral clock via GPR120

Akiko Furutani, Yuko Ikeda, Misa Itokawa, Hiroki Nagahama, Teiji Ohtsu, Naoki Furutani, Mayo Kamagata, Zhi Hong Yang, Akira Hirasawa, Yu Tahara, Shigenobu Shibata

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


The circadian peripheral clock is entrained by restricted feeding (RF) at a fixed time of day, and insulin secretion regulates RF-induced entrainment of the peripheral clock in mice. Thus, carbohydrate-rich food may be ideal for facilitating RF-induced entrainment, although the role of dietary oils in insulin secretion and RF-induced entrainment has not been described. The soybean oil component of standard mouse chow was substituted with fish or soybean oil containing docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA). Tuna oil (high DHA/EPA), menhaden oil (standard), and DHA/EPA dissolved in soybean oil increased insulin secretion and facilitated RF-induced phase shifts of the liver clock as represented by the bioluminescence rhythms of PER2::LUCIFERASE knock-in mice. In this model, insulin depletion blocked the effect of tuna oil and fish oil had no effect on mice deficient for GPR120, a polyunsaturated fatty acid receptor. These results suggest food containing fish oil or DHA/EPA is ideal for adjusting the peripheral clock.

Original languageEnglish
Article numbere0132472
JournalPloS one
Issue number7
Publication statusPublished - 2015 Jul 10
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General


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