Focused ultrasound thermal treatment using cavitation-enhanced ultrasonic heating

Shin Yoshizawa, Ryo Takagi, Hiroshi Sasaki, Kota Goto, Nobutaka Abe, Shohei Kodera, Hiroshi Ishii, Takashi Suzuki, Yoshihiro Muragaki, Hiroshi Iseki, Shin Ichiro Umemura

    Research output: Contribution to journalArticlepeer-review


    High-intensity focused ultrasound (HIFU) causes selective tissue necrosis through heating and is used for a noninvasive treatment of cancer therapy. However, HIFU thermal treatment has a problem of long treatment time because cooling time is needed between two consecutive shots of focused ultrasound exposure to avoid near-field heating owing to heat accumulation. It is known that acoustic cavitation generated in the focal region of HIFU enhances tissue heating. The objective of this study is to develop a method to accelerate HIFU thermal treatment by using cavitation bubbles. Cavitation bubbles were generated at six positions in the direction perpendicular to ultrasound propagation and they were observed by high-speed ultrasound imaging in real time. The coagulation volumes of chicken breast with and without cavitation bubbles were compared. The results show the high efficiency of the proposed HIFU exposure sequence using cavitation-enhanced heating for HIFU thermal treatment.

    Original languageEnglish
    Pages (from-to)SY-3-SY-4
    JournalTransactions of Japanese Society for Medical and Biological Engineering
    Publication statusPublished - 2014 Aug 17


    • Cavitation
    • HIFU
    • Microbubbles

    ASJC Scopus subject areas

    • Biomedical Engineering


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