Formation of an ascorbate-apatite composite layer on titanium

Atsuo Ito*, Yu Sogo, Yuko Ebihara, Masahiro Onoguchi, Ayako Oyane, Noboru Ichinose

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


An ascorbate-apatite composite layer was successfully formed on NaOH- and heat-treated titanium by coprecipitating L-ascorbic acid phosphate and low-crystalline apatite in a supersaturated calcium phosphate solution at 37°C for 48 h. The supersaturated calcium phosphate solutions used have chemical compositions attainable by mixing infusion fluids officially approved for clinical use. The amount of immobilized L-ascorbic acid phosphate ranged from 1.0 to 2.3 μg mm-2, which is most likely to be sufficient for the in vitro osteogenic differentiation of mesenchymal stem cells on titanium. Since ascorbate is important for the collagen synthesis and subsequent osteogenesis of mesenchymal stem cells, titanium coated with the ascorbate-apatite composite layer would be useful as a scaffold in bone tissue engineering and as a bone substitute.

Original languageEnglish
Article numberS17
Pages (from-to)S181-S185
JournalBiomedical Materials
Issue number3
Publication statusPublished - 2007 Sept 1

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


Dive into the research topics of 'Formation of an ascorbate-apatite composite layer on titanium'. Together they form a unique fingerprint.

Cite this