Four aromatic sulfates with an inhibitory effect against HCV NS3 helicase from the crinoid alloeocomatella polycladia

Idam Hermawan; Atsushi Furuta; Masahiro Higashi; Yoshihisa Fujita; Nobuyoshi Akimitsu; Atsuya Yamashita; Kohji Moriishi; Satoshi Tsuneda; Hidenori Tani; Masamichi Nakakoshi; Masayoshi Tsubuki; Yuji Sekiguchi; Naohiro Noda; Junichi Tanaka

doi:10.3390/md15040117

Four aromatic sulfates with an inhibitory effect against HCV NS3 helicase from the crinoid alloeocomatella polycladia

Idam Hermawan, Atsushi Furuta, Masahiro Higashi, Yoshihisa Fujita, Nobuyoshi Akimitsu, Atsuya Yamashita, Kohji Moriishi, Satoshi Tsuneda, Hidenori Tani, Masamichi Nakakoshi, Masayoshi Tsubuki, Yuji Sekiguchi, Naohiro Noda^*, Junichi Tanaka

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Bioassay-guided separation of a lipophilic extract of the crinoid Alloeocomatella polycladia, inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules: cholesterol sulfate and four new aromatic sulfates 1-4. The structures of the aromatics were elucidated by spectroscopic analysis in addition to theoretical studies. The aromatic sulfates 1-4 showed moderate inhibition against NS3 helicase with IC₅₀ values of 71, 95, 7, and 5 μM, respectively.

Original language	English
Article number	117
Journal	Marine Drugs
Volume	15
Issue number	4
DOIs	https://doi.org/10.3390/md15040117
Publication status	Published - 2017 Apr

Keywords

Aromatic sulfates
Crinoid
Hepatitis C virus (HCV)
NS3 helicase

ASJC Scopus subject areas

Drug Discovery

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10.3390/md15040117

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Hermawan, I., Furuta, A., Higashi, M., Fujita, Y., Akimitsu, N., Yamashita, A., Moriishi, K., Tsuneda, S., Tani, H., Nakakoshi, M., Tsubuki, M., Sekiguchi, Y., Noda, N., & Tanaka, J. (2017). Four aromatic sulfates with an inhibitory effect against HCV NS3 helicase from the crinoid alloeocomatella polycladia. Marine Drugs, 15(4), Article 117. https://doi.org/10.3390/md15040117

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abstract = "Bioassay-guided separation of a lipophilic extract of the crinoid Alloeocomatella polycladia, inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules: cholesterol sulfate and four new aromatic sulfates 1-4. The structures of the aromatics were elucidated by spectroscopic analysis in addition to theoretical studies. The aromatic sulfates 1-4 showed moderate inhibition against NS3 helicase with IC50 values of 71, 95, 7, and 5 μM, respectively.",

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AU - Hermawan, Idam

AU - Furuta, Atsushi

AU - Higashi, Masahiro

AU - Fujita, Yoshihisa

AU - Akimitsu, Nobuyoshi

AU - Yamashita, Atsuya

AU - Moriishi, Kohji

AU - Tsuneda, Satoshi

AU - Tani, Hidenori

AU - Nakakoshi, Masamichi

AU - Tsubuki, Masayoshi

AU - Sekiguchi, Yuji

AU - Noda, Naohiro

AU - Tanaka, Junichi

PY - 2017/4

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AB - Bioassay-guided separation of a lipophilic extract of the crinoid Alloeocomatella polycladia, inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules: cholesterol sulfate and four new aromatic sulfates 1-4. The structures of the aromatics were elucidated by spectroscopic analysis in addition to theoretical studies. The aromatic sulfates 1-4 showed moderate inhibition against NS3 helicase with IC50 values of 71, 95, 7, and 5 μM, respectively.

KW - Aromatic sulfates

KW - Crinoid

KW - Hepatitis C virus (HCV)

KW - NS3 helicase

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Four aromatic sulfates with an inhibitory effect against HCV NS3 helicase from the crinoid alloeocomatella polycladia

Abstract

Keywords

ASJC Scopus subject areas

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