From O2 to H2S: A landscape view of gas biology

Misato Kashiba*, Mayumi Kajimura, Nobuhito Goda, Makoto Suematsu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


The majority of molecular oxygen (O2) consumed in the body is used as a substrate of cytochrome c oxidase to maintain oxidative phospholylation for ATP synthesis. Rest of the O2 is used for oxidative biosynthesis including synthesis of vasoactive substances such as prostaglandins and secondary gaseous mediators such as nitric oxide (NO) and carbon monoxide (CO). Thus, O2 is not only used for maintenance of energy supply but also for regulating blood supply into tissues. Nitrous oxide (N2O), laughing gas for anesthesia, is generated endogenously through NO reductase in bacteria and fungi, and has recently been shown to modulate N-methyl-D-aspartic acid (NMDA) receptor function. A number of other biologically active gases could participate in regulation of cell and tissue functions. Carbon dioxide (CO2) is generated mainly through the Krebs cycle as a result of glucose oxidation and serves as a potent vasodilator, and hydrogen sulfide (H2S) synthesized through degradation of cysteine has recently been postulated to be a neuromodulater, although their receptor proteins for signaling have not been verified as a discernible molecular entity. Easy penetration allow these gases to access the inner space of receptor proteins and to execute their biological actions. These gases are generated and consumed in anaerobic bacteria through varied reactions distinct from those in mammals. This review summarizes recent information on mechanisms for gas generation and reception in biological systems.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalKeio Journal of Medicine
Issue number1
Publication statusPublished - 2002
Externally publishedYes


  • Carbon monoxide
  • Gas biology
  • Hydrogen sulfide
  • Nitric oxide
  • Nitrous oxide

ASJC Scopus subject areas

  • Medicine(all)


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