Gastric PCO(2) monitoring system based on a double membrane type PCO(2) sensor

Tetsushi Sekiguchi*, Yuko Nagai, Tetsuya Makino, Kohei Ohno, Michihiro Nakamura, Hidehiro Hosaka, Hideaki Sakio, Satoshi Ohtsu, Hiroyuki Takahashi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Gastric PCO(2) monitoring during canine hemorrhagic shock encountered occasional baseline drift to higher direction when conventional PCO(2) sensor was used. As a result of chemical analysis of gastric juice of dogs and human, hydrogen sulfide and acetic acid were identified as causative compounds. It was speculated that these weak acid molecules would permeate gas-permeable silicone membrane to be accumulated in the inner solution of Severinghaus-type PCO(2) sensors. In order to prevent this phenomenon, double-membrane type PCO(2) sensor was constructed. In this sensor, acid-neutralizing solution was installed between the inner and the outer membranes in order to dissociate weak acid molecules into corresponding ions, which can not diffuse into the inner silicone membrane. In addition, Cu2O particles were mixed in the inner silicone membrane to trap hydrogen sulfide in this membrane. It was confirmed by experiments in vitro that the readings of improved gastric PCO(2) sensors were not affected by acetic acid or hydrogen sulfide. As a result of a preliminary clinical evaluation, continuous monitoring of gastric PCO(2) was carried out for 72 h without detectable baseline drift or the change of sensitivity.

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalSensors and Actuators, B: Chemical
Volume49 B49
Issue number3
Publication statusPublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry


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