GATAe-dependent and -independent expressions of genes in the differentiated endodermal midgut of Drosophila

Takashi Okumura, Reiko Tajiri, Tetsuya Kojima, Kaoru Saigo, Ryutaro Murakami*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Two sequentially-expressed GATA factor genes, serpent (srp) and GATAe, are essential for development of the Drosophila endoderm. The earliest endodermal GATA gene, srp, has been thought to specify the endodermal fate, activating the second GATA gene GATAe, and the latter continues to be expressed in the endodermal midgut throughout life. Previously, we proposed that GATAe establishes and maintains the state of terminal differentiation of the midgut, since some functional genes in the midgut require GATAe activity for their expression. To obtain further evidence of the role of GATAe, we searched for additional genes that are expressed specifically in the midgut in late stages, and examined responses of a total of selected 15 genes to the depletion and overexpression of GATAe. Ten of the 15 genes failed to be expressed in the embryo deficient for GATAe activity, but, the other five genes did not require GATAe. Instead, srp is required for activating the five genes. These observations indicate that GATAe activates a major subset of genes in the midgut, and some other pathway(s) downstream of srp activates other genes.

Original languageEnglish
Pages (from-to)178-186
Number of pages9
JournalGene Expression Patterns
Issue number1-2
Publication statusPublished - 2007 Jan
Externally publishedYes


  • Drosophila melanogaster
  • Endoderm
  • GATA factor
  • GATAe
  • Midgut
  • Serpent
  • Terminal differentiation

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience


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