Genome sequence of the cat pathogen, Chlamydophila felis

Yoshinao Azuma; Hideki Hirakawa; Atsushi Yamashita; Yan Cai; Mohd Akhlakur Rahman; Harumi Suzuki; Shigeki Mitaku; Hidehiro Toh; Susumu Goto; Tomoyuki Murakami; Kazuro Sugi; Hideo Hayashi; Hideto Fukushi; Masahira Hattori; Satoru Kuhara; Mutsunori Shirai

doi:10.1093/dnares/dsi027

Genome sequence of the cat pathogen, Chlamydophila felis

Yoshinao Azuma^*, Hideki Hirakawa, Atsushi Yamashita, Yan Cai, Mohd Akhlakur Rahman, Harumi Suzuki, Shigeki Mitaku, Hidehiro Toh, Susumu Goto, Tomoyuki Murakami, Kazuro Sugi, Hideo Hayashi, Hideto Fukushi, Masahira Hattori, Satoru Kuhara, Mutsunori Shirai

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

Chlamydophila felis (Chlamydia psittaci feline pneumonitis agent) is a worldwide spread pathogen for pneumonia and conjunctivitis in cats. Herein, we determined the entire genomic DNA sequence of the Japanese C. felis strain Fe/C-56 to understand the mechanism of diseases caused by this pathogen. The C. felis genome is composed of a circular 1 166 239 bp chromosome encoding 1005 protein-coding genes and a 7552 bp circular plasmid. Comparison of C. felis gene contents with other Chlamydia species shows that 795 genes are common in the family Chlamydiaceae species and 47 genes are specific to C. felis. Phylogenetic analysis of the common genes reveals that most of the orthologue sets exhibit a similar divergent pattern but 14 C. felis genes accumulate more mutations, implicating that these genes may be involved in the evolutional adaptation to the C. felis-specific niche. Gene distribution and orthologue analyses reveal that two distinctive regions, i.e. the plasticity zone and frequently gene-translocated regions (FGRs), may play important but different roles for chlamydial genome evolution. The genomic DNA sequence of C. felis provides information for comprehension of diseases and elucidation of the chlamydial evolution.

Original language	English
Pages (from-to)	15-23
Number of pages	9
Journal	DNA Research
Volume	13
Issue number	1
DOIs	https://doi.org/10.1093/dnares/dsi027
Publication status	Published - 2006
Externally published	Yes

Keywords

Chlamydia
Comparative genomics
Genome inversion
Infectious disease
Obligate intercellular bacteria

ASJC Scopus subject areas

Genetics
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/dnares/dsi027

Cite this

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title = "Genome sequence of the cat pathogen, Chlamydophila felis",

abstract = "Chlamydophila felis (Chlamydia psittaci feline pneumonitis agent) is a worldwide spread pathogen for pneumonia and conjunctivitis in cats. Herein, we determined the entire genomic DNA sequence of the Japanese C. felis strain Fe/C-56 to understand the mechanism of diseases caused by this pathogen. The C. felis genome is composed of a circular 1 166 239 bp chromosome encoding 1005 protein-coding genes and a 7552 bp circular plasmid. Comparison of C. felis gene contents with other Chlamydia species shows that 795 genes are common in the family Chlamydiaceae species and 47 genes are specific to C. felis. Phylogenetic analysis of the common genes reveals that most of the orthologue sets exhibit a similar divergent pattern but 14 C. felis genes accumulate more mutations, implicating that these genes may be involved in the evolutional adaptation to the C. felis-specific niche. Gene distribution and orthologue analyses reveal that two distinctive regions, i.e. the plasticity zone and frequently gene-translocated regions (FGRs), may play important but different roles for chlamydial genome evolution. The genomic DNA sequence of C. felis provides information for comprehension of diseases and elucidation of the chlamydial evolution.",

keywords = "Chlamydia, Comparative genomics, Genome inversion, Infectious disease, Obligate intercellular bacteria",

author = "Yoshinao Azuma and Hideki Hirakawa and Atsushi Yamashita and Yan Cai and Rahman, {Mohd Akhlakur} and Harumi Suzuki and Shigeki Mitaku and Hidehiro Toh and Susumu Goto and Tomoyuki Murakami and Kazuro Sugi and Hideo Hayashi and Hideto Fukushi and Masahira Hattori and Satoru Kuhara and Mutsunori Shirai",

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volume = "13",

pages = "15--23",

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T1 - Genome sequence of the cat pathogen, Chlamydophila felis

AU - Azuma, Yoshinao

AU - Hirakawa, Hideki

AU - Yamashita, Atsushi

AU - Cai, Yan

AU - Rahman, Mohd Akhlakur

AU - Suzuki, Harumi

AU - Mitaku, Shigeki

AU - Toh, Hidehiro

AU - Goto, Susumu

AU - Murakami, Tomoyuki

AU - Sugi, Kazuro

AU - Hayashi, Hideo

AU - Fukushi, Hideto

AU - Hattori, Masahira

AU - Kuhara, Satoru

AU - Shirai, Mutsunori

PY - 2006

Y1 - 2006

N2 - Chlamydophila felis (Chlamydia psittaci feline pneumonitis agent) is a worldwide spread pathogen for pneumonia and conjunctivitis in cats. Herein, we determined the entire genomic DNA sequence of the Japanese C. felis strain Fe/C-56 to understand the mechanism of diseases caused by this pathogen. The C. felis genome is composed of a circular 1 166 239 bp chromosome encoding 1005 protein-coding genes and a 7552 bp circular plasmid. Comparison of C. felis gene contents with other Chlamydia species shows that 795 genes are common in the family Chlamydiaceae species and 47 genes are specific to C. felis. Phylogenetic analysis of the common genes reveals that most of the orthologue sets exhibit a similar divergent pattern but 14 C. felis genes accumulate more mutations, implicating that these genes may be involved in the evolutional adaptation to the C. felis-specific niche. Gene distribution and orthologue analyses reveal that two distinctive regions, i.e. the plasticity zone and frequently gene-translocated regions (FGRs), may play important but different roles for chlamydial genome evolution. The genomic DNA sequence of C. felis provides information for comprehension of diseases and elucidation of the chlamydial evolution.

AB - Chlamydophila felis (Chlamydia psittaci feline pneumonitis agent) is a worldwide spread pathogen for pneumonia and conjunctivitis in cats. Herein, we determined the entire genomic DNA sequence of the Japanese C. felis strain Fe/C-56 to understand the mechanism of diseases caused by this pathogen. The C. felis genome is composed of a circular 1 166 239 bp chromosome encoding 1005 protein-coding genes and a 7552 bp circular plasmid. Comparison of C. felis gene contents with other Chlamydia species shows that 795 genes are common in the family Chlamydiaceae species and 47 genes are specific to C. felis. Phylogenetic analysis of the common genes reveals that most of the orthologue sets exhibit a similar divergent pattern but 14 C. felis genes accumulate more mutations, implicating that these genes may be involved in the evolutional adaptation to the C. felis-specific niche. Gene distribution and orthologue analyses reveal that two distinctive regions, i.e. the plasticity zone and frequently gene-translocated regions (FGRs), may play important but different roles for chlamydial genome evolution. The genomic DNA sequence of C. felis provides information for comprehension of diseases and elucidation of the chlamydial evolution.

KW - Chlamydia

KW - Comparative genomics

KW - Genome inversion

KW - Infectious disease

KW - Obligate intercellular bacteria

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Genome sequence of the cat pathogen, Chlamydophila felis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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