GnIH control of feeding and reproductive behaviors

Kazuyoshi Tsutsui*, Takayoshi Ubuka

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    41 Citations (Scopus)


    In 2000, Tsutsui and colleagues discovered a neuropeptide gonadotropin-inhibitory hormone (GnIH) that inhibits gonadotropin release in birds. Subsequently, extensive studies during the last 15 years have demonstrated that GnIH is a key neurohormone that regulates reproduction in vertebrates, acting in the brain and on the pituitary to modulate reproduction and reproductive behavior. On the other hand, deprivation of food and other metabolic challenges inhibit the reproductive axis as well as sexual motivation. Interestingly, recent studies have further indicated that GnIH controls feeding behavior in vertebrates, such as in birds and mammals. This review summarizes the discovery of GnIH and its conservation in vertebrates and the neuroendocrine control of feeding behavior and reproductive behavior by GnIH.

    Original languageEnglish
    Article number170
    JournalFrontiers in Endocrinology
    Issue numberDEC
    Publication statusPublished - 2016


    • Feeding behavior
    • Gonadotropin-inhibitory hormone
    • Gonadotropin-releasing hormone
    • Gonadotropins
    • Reproduction
    • Reproductive behavior

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism


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