Gracilioethers A-C, antimalarial metabolites from the marine sponge Agelas gracilis

Reiko Ueoka, Yoichi Nakao*, Shizuka Kawatsu, Junko Yaegashi, Yoshitsugu Matsumoto, Shigeki Matsunaga, Kazuo Furihata, Rob W.M. Van Soest, Nobuhiro Fusetani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)


(Chemical Equation Presented) Three new antiprotozoan compounds, gracilioethers A-C (1-3), have been isolated from the marine sponge Agelas gracilis. Their structures were elucidated on the basis of spectroscopic and chemical methods. Gracilioethers A-C showed antimalarial activity against Plasmodium falciparum with IC50 values of 0.5-10 μg/mL, whereas gracilioether B (2) also showed antileishmanial activity.

Original languageEnglish
Pages (from-to)4203-4207
Number of pages5
JournalJournal of Organic Chemistry
Issue number11
Publication statusPublished - 2009 Jun 5

ASJC Scopus subject areas

  • Organic Chemistry


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