Grafting poly(ethylene glycol) to a glass surface via a photocleavable linker for light-induced cell micropatterning and cell proliferation control

Yukiko Kikuchi; Jun Nakanishi; Hidekazu Nakayama; Takahiro Shimizu; Yutaro Yoshino; Kazuo Yamaguchi; Yasuhiko Yoshida; Yasuhiro Horiike

doi:10.1246/cl.2008.1062

Grafting poly(ethylene glycol) to a glass surface via a photocleavable linker for light-induced cell micropatterning and cell proliferation control

Yukiko Kikuchi, Jun Nakanishi^*, Hidekazu Nakayama, Takahiro Shimizu, Yutaro Yoshino, Kazuo Yamaguchi, Yasuhiko Yoshida, Yasuhiro Horiike

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

This paper describes a glass substrate having a photocleavable poly(ethylene glycol) (PEG) designed for light-induced cell micropatterning. The substrate changed from non-cell-adhesive to cell-adhesive by the photocleavage of PEG. Cellular patterns maintained for more than 17 days, and they were able to be changed to control cell migration and proliferation at multi- and single-cell levels by irradiating their adjacent regions during cell cultivation.

Original language	English
Pages (from-to)	1062-1063
Number of pages	2
Journal	Chemistry Letters
Volume	37
Issue number	10
DOIs	https://doi.org/10.1246/cl.2008.1062
Publication status	Published - 2008
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)

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10.1246/cl.2008.1062

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AU - Kikuchi, Yukiko

AU - Nakanishi, Jun

AU - Nakayama, Hidekazu

AU - Shimizu, Takahiro

AU - Yoshino, Yutaro

AU - Yamaguchi, Kazuo

AU - Yoshida, Yasuhiko

AU - Horiike, Yasuhiro

PY - 2008

Y1 - 2008

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AB - This paper describes a glass substrate having a photocleavable poly(ethylene glycol) (PEG) designed for light-induced cell micropatterning. The substrate changed from non-cell-adhesive to cell-adhesive by the photocleavage of PEG. Cellular patterns maintained for more than 17 days, and they were able to be changed to control cell migration and proliferation at multi- and single-cell levels by irradiating their adjacent regions during cell cultivation.

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Grafting poly(ethylene glycol) to a glass surface via a photocleavable linker for light-induced cell micropatterning and cell proliferation control

Abstract

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