Haemostatic effects of fibrinogen y chain dodecapeptide-conjugates as platelet substitutes

Yosuke Okamura; Ippei Maekawa; Toshinori Fujie; Shinji Takeoka; Makoto Handa; Yasuo Ikeda

Haemostatic effects of fibrinogen y chain dodecapeptide-conjugates as platelet substitutes

Yosuke Okamura^*, Ippei Maekawa, Toshinori Fujie, Shinji Takeoka, Makoto Handa, Yasuo Ikeda

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

We have studied prototypes of platelet substitutes by conjugating the dodecapeptide (H12); a part of the amino acid sequence of fibrinogen, to the surface of polymerized albumin particles (polyAlb) or phospholipid vesicles (vesicle). Both H12-polyAlb and H12-vesicle showed a hemostatic effect, based on the analysis of the tail bleeding time of thrombocytopenic rats. The H12-polyAlb was more effective than the H12-vesicle.

Original language	English
Number of pages	1
Publication status	Published - 2005 Dec 1
Event	54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: 2005 May 25 → 2005 May 27

Conference

Conference	54th SPSJ Annual Meeting 2005
Country/Territory	Japan
City	Yokohama
Period	05/5/25 → 05/5/27

Keywords

Albumin
Fibrinogen γ chain dodecapeptide (H12)
Haemostatic effect
Platelet substitutes
Thrombocytopenic rats
Vesicles

ASJC Scopus subject areas

Engineering(all)

Cite this

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title = "Haemostatic effects of fibrinogen y chain dodecapeptide-conjugates as platelet substitutes",

abstract = "We have studied prototypes of platelet substitutes by conjugating the dodecapeptide (H12); a part of the amino acid sequence of fibrinogen, to the surface of polymerized albumin particles (polyAlb) or phospholipid vesicles (vesicle). Both H12-polyAlb and H12-vesicle showed a hemostatic effect, based on the analysis of the tail bleeding time of thrombocytopenic rats. The H12-polyAlb was more effective than the H12-vesicle.",

keywords = "Albumin, Fibrinogen γ chain dodecapeptide (H12), Haemostatic effect, Platelet substitutes, Thrombocytopenic rats, Vesicles",

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TY - CONF

T1 - Haemostatic effects of fibrinogen y chain dodecapeptide-conjugates as platelet substitutes

AU - Okamura, Yosuke

AU - Maekawa, Ippei

AU - Fujie, Toshinori

AU - Takeoka, Shinji

AU - Handa, Makoto

AU - Ikeda, Yasuo

PY - 2005/12/1

Y1 - 2005/12/1

N2 - We have studied prototypes of platelet substitutes by conjugating the dodecapeptide (H12); a part of the amino acid sequence of fibrinogen, to the surface of polymerized albumin particles (polyAlb) or phospholipid vesicles (vesicle). Both H12-polyAlb and H12-vesicle showed a hemostatic effect, based on the analysis of the tail bleeding time of thrombocytopenic rats. The H12-polyAlb was more effective than the H12-vesicle.

AB - We have studied prototypes of platelet substitutes by conjugating the dodecapeptide (H12); a part of the amino acid sequence of fibrinogen, to the surface of polymerized albumin particles (polyAlb) or phospholipid vesicles (vesicle). Both H12-polyAlb and H12-vesicle showed a hemostatic effect, based on the analysis of the tail bleeding time of thrombocytopenic rats. The H12-polyAlb was more effective than the H12-vesicle.

KW - Albumin

KW - Fibrinogen γ chain dodecapeptide (H12)

KW - Haemostatic effect

KW - Platelet substitutes

KW - Thrombocytopenic rats

KW - Vesicles

UR - http://www.scopus.com/inward/record.url?scp=33645642239&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645642239&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33645642239

T2 - 54th SPSJ Annual Meeting 2005

Y2 - 25 May 2005 through 27 May 2005

ER -

Haemostatic effects of fibrinogen y chain dodecapeptide-conjugates as platelet substitutes

Abstract

Conference

Keywords

ASJC Scopus subject areas

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