High intensity interval training and molecular adaptive response of skeletal muscle

Ferenc Torma; Zoltan Gombos; Matyas Jokai; Masaki Takeda; Tatsuya Mimura; Zsolt Radak

doi:10.1016/j.smhs.2019.08.003

High intensity interval training and molecular adaptive response of skeletal muscle

Ferenc Torma, Zoltan Gombos, Matyas Jokai, Masaki Takeda, Tatsuya Mimura, Zsolt Radak^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

29 Citations (Scopus)

Abstract

Increased cardiovascular fitness, V˙O_2max, is associated with enhanced endurance capacity and a decreased rate of mortality. High intensity interval training (HIIT) is one of the best methods to increase V˙O_2max and endurance capacity for top athletes and for the general public as well. Because of the high intensity of this type of training, the adaptive response is not restricted to Type I fibers, as found for moderate intensity exercise of long duration. Even with a short exercise duration, HIIT can induce activation of AMPK, PGC-1α, SIRT1 and ROS pathway as well as by the modulation of Ca²⁺ homeostasis, leading to enhanced mitochondrial biogenesis, and angiogenesis. The present review summarizes the current knowledge of the adaptive response of HIIT.

Original language	English
Pages (from-to)	24-32
Number of pages	9
Journal	Sports Medicine and Health Science
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/j.smhs.2019.08.003
Publication status	Published - 2019 Dec
Externally published	Yes

Keywords

Cellular adaptation
High intensity interval training
Maximal oxygen uptake
Mitochondrial biogenesis
Molecular pathways
Redox signaling

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

Access to Document

10.1016/j.smhs.2019.08.003

Cite this

@article{d593645019674a31abfc3b6e447bb785,

title = "High intensity interval training and molecular adaptive response of skeletal muscle",

abstract = "Increased cardiovascular fitness, V˙O2max, is associated with enhanced endurance capacity and a decreased rate of mortality. High intensity interval training (HIIT) is one of the best methods to increase V˙O2max and endurance capacity for top athletes and for the general public as well. Because of the high intensity of this type of training, the adaptive response is not restricted to Type I fibers, as found for moderate intensity exercise of long duration. Even with a short exercise duration, HIIT can induce activation of AMPK, PGC-1α, SIRT1 and ROS pathway as well as by the modulation of Ca2+ homeostasis, leading to enhanced mitochondrial biogenesis, and angiogenesis. The present review summarizes the current knowledge of the adaptive response of HIIT.",

keywords = "Cellular adaptation, High intensity interval training, Maximal oxygen uptake, Mitochondrial biogenesis, Molecular pathways, Redox signaling",

author = "Ferenc Torma and Zoltan Gombos and Matyas Jokai and Masaki Takeda and Tatsuya Mimura and Zsolt Radak",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = dec,

doi = "10.1016/j.smhs.2019.08.003",

language = "English",

volume = "1",

pages = "24--32",

journal = "Sports Medicine and Health Science",

issn = "2666-3376",

publisher = "KeAi Communications Co",

number = "1",

}

TY - JOUR

T1 - High intensity interval training and molecular adaptive response of skeletal muscle

AU - Torma, Ferenc

AU - Gombos, Zoltan

AU - Jokai, Matyas

AU - Takeda, Masaki

AU - Mimura, Tatsuya

AU - Radak, Zsolt

PY - 2019/12

Y1 - 2019/12

N2 - Increased cardiovascular fitness, V˙O2max, is associated with enhanced endurance capacity and a decreased rate of mortality. High intensity interval training (HIIT) is one of the best methods to increase V˙O2max and endurance capacity for top athletes and for the general public as well. Because of the high intensity of this type of training, the adaptive response is not restricted to Type I fibers, as found for moderate intensity exercise of long duration. Even with a short exercise duration, HIIT can induce activation of AMPK, PGC-1α, SIRT1 and ROS pathway as well as by the modulation of Ca2+ homeostasis, leading to enhanced mitochondrial biogenesis, and angiogenesis. The present review summarizes the current knowledge of the adaptive response of HIIT.

AB - Increased cardiovascular fitness, V˙O2max, is associated with enhanced endurance capacity and a decreased rate of mortality. High intensity interval training (HIIT) is one of the best methods to increase V˙O2max and endurance capacity for top athletes and for the general public as well. Because of the high intensity of this type of training, the adaptive response is not restricted to Type I fibers, as found for moderate intensity exercise of long duration. Even with a short exercise duration, HIIT can induce activation of AMPK, PGC-1α, SIRT1 and ROS pathway as well as by the modulation of Ca2+ homeostasis, leading to enhanced mitochondrial biogenesis, and angiogenesis. The present review summarizes the current knowledge of the adaptive response of HIIT.

KW - Cellular adaptation

KW - High intensity interval training

KW - Maximal oxygen uptake

KW - Mitochondrial biogenesis

KW - Molecular pathways

KW - Redox signaling

UR - http://www.scopus.com/inward/record.url?scp=85089533432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85089533432&partnerID=8YFLogxK

U2 - 10.1016/j.smhs.2019.08.003

DO - 10.1016/j.smhs.2019.08.003

M3 - Review article

AN - SCOPUS:85089533432

SN - 2666-3376

VL - 1

SP - 24

EP - 32

JO - Sports Medicine and Health Science

JF - Sports Medicine and Health Science

IS - 1

ER -

High intensity interval training and molecular adaptive response of skeletal muscle

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this