High intensity interval training and molecular adaptive response of skeletal muscle

Ferenc Torma, Zoltan Gombos, Matyas Jokai, Masaki Takeda, Tatsuya Mimura, Zsolt Radak*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

29 Citations (Scopus)


Increased cardiovascular fitness, V˙O2max, is associated with enhanced endurance capacity and a decreased rate of mortality. High intensity interval training (HIIT) is one of the best methods to increase V˙O2max and endurance capacity for top athletes and for the general public as well. Because of the high intensity of this type of training, the adaptive response is not restricted to Type I fibers, as found for moderate intensity exercise of long duration. Even with a short exercise duration, HIIT can induce activation of AMPK, PGC-1α, SIRT1 and ROS pathway as well as by the modulation of Ca2+ homeostasis, leading to enhanced mitochondrial biogenesis, and angiogenesis. The present review summarizes the current knowledge of the adaptive response of HIIT.

Original languageEnglish
Pages (from-to)24-32
Number of pages9
JournalSports Medicine and Health Science
Issue number1
Publication statusPublished - 2019 Dec
Externally publishedYes


  • Cellular adaptation
  • High intensity interval training
  • Maximal oxygen uptake
  • Mitochondrial biogenesis
  • Molecular pathways
  • Redox signaling

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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