Highly efficient total synthesis of (+)-citreoviral

Yoshihisa Murata*, Tomoyuki Kamino, Toshiaki Aoki, Seijiro Hosokawa, Susumu Kobayashi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Only eight steps were required for the total synthesis of (+)-citreoviral (3) from chiral imide 1 in 18% overall yield. The key steps included a highly anti-selective aldol reaction, the stereoselective iodolactonization of a γ,δ-unsaturated β-hydroxyimide, and an intramolecular S N2 reaction of a tertiary alcohol to form intermediate 2.

Original languageEnglish
Pages (from-to)3175-3177
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number24
Publication statusPublished - 2004 Jun 14
Externally publishedYes


  • Alcohols
  • Aldol reaction
  • Lactones
  • Natural products
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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