Highly enantioselective addition of dialkylzincs to aromatic aldehydes using 1-phenyl-2-(1-pyrrolidinyl)-1-propanol as a chiral catalyst

Kenso Soai; Takashi Konishi; Takanori Shibata

doi:10.3987/COM-99-8532

Highly enantioselective addition of dialkylzincs to aromatic aldehydes using 1-phenyl-2-(1-pyrrolidinyl)-1-propanol as a chiral catalyst

Kenso Soai^*, Takashi Konishi, Takanori Shibata

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

(1S,2R)- and (1R,2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol catalyzes the enantioselective addition of dialkylzincs to aromatic aldehydes to afford enantiomerically enriched aromatic, sec-alcohols with up to 92% enantiomeric excess.

Original language	English
Pages (from-to)	1421-1426
Number of pages	6
Journal	Heterocycles
Volume	51
Issue number	6
DOIs	https://doi.org/10.3987/COM-99-8532
Publication status	Published - 1999 Jun 1
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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title = "Highly enantioselective addition of dialkylzincs to aromatic aldehydes using 1-phenyl-2-(1-pyrrolidinyl)-1-propanol as a chiral catalyst",

abstract = "(1S,2R)- and (1R,2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol catalyzes the enantioselective addition of dialkylzincs to aromatic aldehydes to afford enantiomerically enriched aromatic, sec-alcohols with up to 92% enantiomeric excess.",

author = "Kenso Soai and Takashi Konishi and Takanori Shibata",

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T1 - Highly enantioselective addition of dialkylzincs to aromatic aldehydes using 1-phenyl-2-(1-pyrrolidinyl)-1-propanol as a chiral catalyst

AU - Soai, Kenso

AU - Konishi, Takashi

AU - Shibata, Takanori

PY - 1999/6/1

Y1 - 1999/6/1

N2 - (1S,2R)- and (1R,2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol catalyzes the enantioselective addition of dialkylzincs to aromatic aldehydes to afford enantiomerically enriched aromatic, sec-alcohols with up to 92% enantiomeric excess.

AB - (1S,2R)- and (1R,2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol catalyzes the enantioselective addition of dialkylzincs to aromatic aldehydes to afford enantiomerically enriched aromatic, sec-alcohols with up to 92% enantiomeric excess.

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M3 - Article

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JF - Heterocycles

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ER -

Highly enantioselective addition of dialkylzincs to aromatic aldehydes using 1-phenyl-2-(1-pyrrolidinyl)-1-propanol as a chiral catalyst

Abstract

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