TY - JOUR
T1 - Highly enantioselective asymmetric autocatalysis of pyrimidin-5-yl alkanol induced by chiral 1,3-disubstituted hydrocarbon allenes
AU - Sato, Itaru
AU - Matsueda, Yohei
AU - Kadowaki, Kousuke
AU - Yonekubo, Shigeru
AU - Shibata, Takanori
AU - Soai, Kenso
PY - 2002/11/26
Y1 - 2002/11/26
N2 - 1,3-Disubstituted chiral allenes without any heteroatoms act as chiral initiators in the addition of (i-Pr)2Zn to pyrimidine-5-carbaldehyde to afford, in combination with the subsequent asymmetric autocatalysis, chiral pyrimidin-5-yl alkanols with up to 98% ee. The absolute configuration of the pyrimidin-5-yl alkanol formed depend on that of the chiral allene.
AB - 1,3-Disubstituted chiral allenes without any heteroatoms act as chiral initiators in the addition of (i-Pr)2Zn to pyrimidine-5-carbaldehyde to afford, in combination with the subsequent asymmetric autocatalysis, chiral pyrimidin-5-yl alkanols with up to 98% ee. The absolute configuration of the pyrimidin-5-yl alkanol formed depend on that of the chiral allene.
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U2 - 10.1002/1522-2675(200210)85:10<3383::AID-HLCA3383>3.0.CO;2-B
DO - 10.1002/1522-2675(200210)85:10<3383::AID-HLCA3383>3.0.CO;2-B
M3 - Article
AN - SCOPUS:0036428385
SN - 0018-019X
VL - 85
SP - 3383
EP - 3387
JO - Helvetica Chimica Acta
JF - Helvetica Chimica Acta
IS - 10
ER -