Highly enantioselective synthesis of a chiral 3-quinolylalkanol by an asymmetric autocatalytic reaction

Takanori Shibata; Kaori Choji; Hiroshi Morioka; Tadakatsu Hayase; Kenso Soai

doi:10.1039/cc9960000751

Highly enantioselective synthesis of a chiral 3-quinolylalkanol by an asymmetric autocatalytic reaction

Takanori Shibata^*, Kaori Choji, Hiroshi Morioka, Tadakatsu Hayase, Kenso Soai

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

A catalytic amount of a chiral zinc alkoxide of 2-methyl-1-(3-quinolyl)propan-1-ol catalyses the enantioselective alkylation of quinoline-3-carbaldehyde by diisopropylzine to afford 2-methyl-1-(3-quinolyl)propan-1-ol with the same configuration in high ee (up to 94%).

Original language	English
Pages (from-to)	751-752
Number of pages	2
Journal	Chemical Communications
Issue number	6
DOIs	https://doi.org/10.1039/cc9960000751
Publication status	Published - 1996 Jan 1
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Highly enantioselective synthesis of a chiral 3-quinolylalkanol by an asymmetric autocatalytic reaction",

abstract = "A catalytic amount of a chiral zinc alkoxide of 2-methyl-1-(3-quinolyl)propan-1-ol catalyses the enantioselective alkylation of quinoline-3-carbaldehyde by diisopropylzine to afford 2-methyl-1-(3-quinolyl)propan-1-ol with the same configuration in high ee (up to 94%).",

author = "Takanori Shibata and Kaori Choji and Hiroshi Morioka and Tadakatsu Hayase and Kenso Soai",

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T1 - Highly enantioselective synthesis of a chiral 3-quinolylalkanol by an asymmetric autocatalytic reaction

AU - Shibata, Takanori

AU - Choji, Kaori

AU - Morioka, Hiroshi

AU - Hayase, Tadakatsu

AU - Soai, Kenso

PY - 1996/1/1

Y1 - 1996/1/1

N2 - A catalytic amount of a chiral zinc alkoxide of 2-methyl-1-(3-quinolyl)propan-1-ol catalyses the enantioselective alkylation of quinoline-3-carbaldehyde by diisopropylzine to afford 2-methyl-1-(3-quinolyl)propan-1-ol with the same configuration in high ee (up to 94%).

AB - A catalytic amount of a chiral zinc alkoxide of 2-methyl-1-(3-quinolyl)propan-1-ol catalyses the enantioselective alkylation of quinoline-3-carbaldehyde by diisopropylzine to afford 2-methyl-1-(3-quinolyl)propan-1-ol with the same configuration in high ee (up to 94%).

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U2 - 10.1039/cc9960000751

DO - 10.1039/cc9960000751

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Highly enantioselective synthesis of a chiral 3-quinolylalkanol by an asymmetric autocatalytic reaction

Abstract

ASJC Scopus subject areas

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