HOXB7 induces STAT3-mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells

Kazushi Azuma, Mai Sakamoto, Shota Katayama, Atsuka Matsui, Kazuya Nakamichi, Naoki Goshima, Shinya Watanabe, Jun Nakayama*, Kentaro Semba*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The homeobox family genes are often dysregulated in various cancer types. Particularly HOXB7 amplification and overexpression correlate with poor prognosis in various cancer such as gastric, pancreatic, and lung cancers. Moreover, HOXB7 is known to contribute to cancer progression by promoting epithelial to mesenchymal transition, anticancer drug resistance, and angiogenesis. In this study, we show that HOXB7 is coamplified with ERBB2 in a subset of breast cancer patients and HOXB7 expression correlates with poor prognosis in HER2-positive breast cancer patients. This clinical observation is supported by the following results—HOXB7 overexpression in an immortalized murine mammary gland epithelial cell line NMuMG induces cellular transformation in vitro, tumorigenesis, and lung metastasis through the activation of JAK-STAT signaling.

Original languageEnglish
Pages (from-to)277-287
Number of pages11
JournalGenes to Cells
Volume28
Issue number4
DOIs
Publication statusPublished - 2023 Apr

Keywords

  • ERBB2
  • HOXB7
  • NMuMG
  • breast cancer
  • metastasis
  • oncogene

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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