Hydroxyapatite containing immobilized collagen and fibronectin promotes bone regeneration

Tomonori Matsuno*, Eiji Uchimura, Tadao Ohno, Tazuko Satoh, Yu Sogo, Atsuo Ito, Atsushi Yamazaki, Yusuke Ishikawa, Nao Kondo, Noboru Ichinose

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)


Hydroxyapatite (HA) is often used for bone tissue engineering. In this study, we evaluated a novel method for preparing HA containing immobilized collagen and fibronectin (HICF). We examined the ability of this material to promote bone regeneration in vitro and in vivo. Cell pseudopodia were grown on a HICF disk in vitro. Numerous points of new bone formation were observed around HICF granules at 4 weeks in vivo. These results indicate that HICF provides a surface that promotes bone regeneration.

Original languageEnglish
Pages (from-to)330-331
Number of pages2
JournalInternational Congress Series
Publication statusPublished - 2005 Sept


  • Bone regeneration
  • Collagen
  • Fibronectin
  • Hydroxyapatite
  • Immobilize

ASJC Scopus subject areas

  • Medicine(all)


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