Hypothalamic region facilitating shivering in rats

Mutsumi Tanaka, Mio Tonouchi, Takayoshi Hosono, Kei Nagashima, Motoko Yanase-Fujiwara, Kazuyuki Kanosue*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Although the posterior part of the hypothalamus has long been considered important for thermoregulatory shivering, it is unknown whether the neurons there or the passing fibers are implicated in the response. Exposure of urethane-anesthetized rats to cold (15-21°C) elicits shivering. An injection of muscimol (0.5mM), a GABAA receptor agonist, into the medial part of the hypothalamus, including the dorsomedial and posterior nuclei, suppressed the cold-induced shivering. This result suggests that neurons having an excitatory effect on shivering are in this region of the hypothalamus.

Original languageEnglish
Pages (from-to)625-629
Number of pages5
JournalJapanese Journal of Physiology
Issue number5
Publication statusPublished - 2001 Dec 1
Externally publishedYes


  • Dorsomedial hypothalamus
  • Posterior hypothalamus
  • Shivering

ASJC Scopus subject areas

  • Physiology


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