TY - JOUR
T1 - Hypothalamic region facilitating shivering in rats
AU - Tanaka, Mutsumi
AU - Tonouchi, Mio
AU - Hosono, Takayoshi
AU - Nagashima, Kei
AU - Yanase-Fujiwara, Motoko
AU - Kanosue, Kazuyuki
PY - 2001/12/1
Y1 - 2001/12/1
N2 - Although the posterior part of the hypothalamus has long been considered important for thermoregulatory shivering, it is unknown whether the neurons there or the passing fibers are implicated in the response. Exposure of urethane-anesthetized rats to cold (15-21°C) elicits shivering. An injection of muscimol (0.5mM), a GABAA receptor agonist, into the medial part of the hypothalamus, including the dorsomedial and posterior nuclei, suppressed the cold-induced shivering. This result suggests that neurons having an excitatory effect on shivering are in this region of the hypothalamus.
AB - Although the posterior part of the hypothalamus has long been considered important for thermoregulatory shivering, it is unknown whether the neurons there or the passing fibers are implicated in the response. Exposure of urethane-anesthetized rats to cold (15-21°C) elicits shivering. An injection of muscimol (0.5mM), a GABAA receptor agonist, into the medial part of the hypothalamus, including the dorsomedial and posterior nuclei, suppressed the cold-induced shivering. This result suggests that neurons having an excitatory effect on shivering are in this region of the hypothalamus.
KW - Dorsomedial hypothalamus
KW - Posterior hypothalamus
KW - Shivering
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U2 - 10.2170/jjphysiol.51.625
DO - 10.2170/jjphysiol.51.625
M3 - Article
C2 - 11734085
AN - SCOPUS:0035676668
SN - 1880-6546
VL - 51
SP - 625
EP - 629
JO - Journal of Physiological Sciences
JF - Journal of Physiological Sciences
IS - 5
ER -