Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain

Motoyuki Shimizu, Keiichi Higuchi, Beth Bennett, Chen Xia, Tadao Tsuboyama, Soichiro Kasai, Takuya Chiba, Hiromi Fujisawa, Kumiko Kogishi, Haruo Kitado, Mitsutoshi Kimoto, Norikazu Takeda, Mutsumi Matsushita, Hideo Okumura, Tadao Serikawa, Takashi Nakamura, Thomas E. Johnson, Masanori Hosokawa*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

94 Citations (Scopus)


The whole genome scan for quantitative trait loci (QTLs) specifying peak bone mass was performed with the F2 intercrosses of SAMP6, an established murine model of senile osteoporosis, exhibiting a significantly lower peak bone mass, and SAMP2, exhibiting a higher peak bone mass. Cortical thickness index (CTI), a parameter of bone mass of femurs, was measured in 488 F2 progeny at 4 months of age, when the animals attained peak bone mass by microphotodensitometry. Genetic markers were typed at 90 loci spanning all chromosomes except the Y. By interval mapping of 246 male F2 mice, two loci were identified with significant linkage to peak bone mass, one on Chromosome (Chr) 11 and another on Chr 13, with a maximum lod score of 10.8 (22.2% of the total variance) and 5.8 (10.0%), respectively. Another locus on the X Chr was suggestive of a QTL associated oppositely with a low peak bone mass to the SAMP2 allele. This association was consistent with the distribution of peak bone mass in the F1 and F2. These findings should be useful to elucidate the genetics of osteoporosis.

Original languageEnglish
Pages (from-to)81-87
Number of pages7
JournalMammalian Genome
Issue number2
Publication statusPublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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