Identification of renieramycin a as an antileishmanial substance in a marine sponge neopetrosia sp.

Yoichi Nakao; Takeru Shiroiwa; Shuhei Murayama; Shigeki Matsunaga; Yasuyuki Goto; Yoshitsugu Matsumoto; Nobuhiro Fusetani

doi:10.3390/md202055

Identification of renieramycin a as an antileishmanial substance in a marine sponge neopetrosia sp.

Yoichi Nakao, Takeru Shiroiwa, Shuhei Murayama, Shigeki Matsunaga, Yasuyuki Goto, Yoshitsugu Matsumoto, Nobuhiro Fusetani^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC₅₀ value of 0.2 µg/mL.

Original language	English
Pages (from-to)	55-62
Number of pages	8
Journal	Marine Drugs
Volume	2
Issue number	2
DOIs	https://doi.org/10.3390/md202055
Publication status	Published - 2004 Jun
Externally published	Yes

Keywords

Leishmaniasis
Marine sponge
Renieramycin A

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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10.3390/md202055

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title = "Identification of renieramycin a as an antileishmanial substance in a marine sponge neopetrosia sp.",

abstract = "The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC50 value of 0.2 µg/mL.",

keywords = "Leishmaniasis, Marine sponge, Renieramycin A",

author = "Yoichi Nakao and Takeru Shiroiwa and Shuhei Murayama and Shigeki Matsunaga and Yasuyuki Goto and Yoshitsugu Matsumoto and Nobuhiro Fusetani",

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year = "2004",

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language = "English",

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T1 - Identification of renieramycin a as an antileishmanial substance in a marine sponge neopetrosia sp.

AU - Nakao, Yoichi

AU - Shiroiwa, Takeru

AU - Murayama, Shuhei

AU - Matsunaga, Shigeki

AU - Goto, Yasuyuki

AU - Matsumoto, Yoshitsugu

AU - Fusetani, Nobuhiro

PY - 2004/6

Y1 - 2004/6

N2 - The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC50 value of 0.2 µg/mL.

AB - The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC50 value of 0.2 µg/mL.

KW - Leishmaniasis

KW - Marine sponge

KW - Renieramycin A

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JO - Marine Drugs

JF - Marine Drugs

IS - 2

ER -

Identification of renieramycin a as an antileishmanial substance in a marine sponge neopetrosia sp.

Abstract

Keywords

ASJC Scopus subject areas

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