Implications of protein degradation in aging

Sataro Goto*, Ryoya Takahashi, Atsushi Kumiyama, Zsolt Radák, Toshiaki Hayashi, Masaki Takenouchi, Ryoichi Abe

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Aging is characterized by accumulation of potentially harmful altered proteins that could lead to gradual deterioration of cellular functions and eventually result in increased probability of death. Metabolic turnover of proteins thus plays an essential role in maintaining the life of an organism. In this article we summarize our current knowledge on age-related changes in protein turnover with special reference to degradation. Increase in half-life of proteins with advancing age is well documented. Qualitative rather than quantitative changes of proteasomes appear to be responsible for this change. Dietary restriction and moderate long-term exercise seem to restore higher proteasome activity and turnover rate of proteins in aged animals.

Original languageEnglish
Pages (from-to)54-64
Number of pages11
JournalAnnals of the New York Academy of Sciences
Publication statusPublished - 2001
Externally publishedYes


  • Dietary restriction
  • Exercise
  • Hepatocytes
  • Proteasomes
  • Ubiquitin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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