Implications of protein degradation in aging

Sataro Goto; Ryoya Takahashi; Atsushi Kumiyama; Zsolt Radák; Toshiaki Hayashi; Masaki Takenouchi; Ryoichi Abe

doi:10.1111/j.1749-6632.2001.tb05635.x

Implications of protein degradation in aging

Sataro Goto^*, Ryoya Takahashi, Atsushi Kumiyama, Zsolt Radák, Toshiaki Hayashi, Masaki Takenouchi, Ryoichi Abe

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Aging is characterized by accumulation of potentially harmful altered proteins that could lead to gradual deterioration of cellular functions and eventually result in increased probability of death. Metabolic turnover of proteins thus plays an essential role in maintaining the life of an organism. In this article we summarize our current knowledge on age-related changes in protein turnover with special reference to degradation. Increase in half-life of proteins with advancing age is well documented. Qualitative rather than quantitative changes of proteasomes appear to be responsible for this change. Dietary restriction and moderate long-term exercise seem to restore higher proteasome activity and turnover rate of proteins in aged animals.

Original language	English
Pages (from-to)	54-64
Number of pages	11
Journal	Annals of the New York Academy of Sciences
Volume	928
DOIs	https://doi.org/10.1111/j.1749-6632.2001.tb05635.x
Publication status	Published - 2001
Externally published	Yes

Keywords

Dietary restriction
Exercise
Hepatocytes
Proteasomes
Ubiquitin

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

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10.1111/j.1749-6632.2001.tb05635.x

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title = "Implications of protein degradation in aging",

abstract = "Aging is characterized by accumulation of potentially harmful altered proteins that could lead to gradual deterioration of cellular functions and eventually result in increased probability of death. Metabolic turnover of proteins thus plays an essential role in maintaining the life of an organism. In this article we summarize our current knowledge on age-related changes in protein turnover with special reference to degradation. Increase in half-life of proteins with advancing age is well documented. Qualitative rather than quantitative changes of proteasomes appear to be responsible for this change. Dietary restriction and moderate long-term exercise seem to restore higher proteasome activity and turnover rate of proteins in aged animals.",

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T1 - Implications of protein degradation in aging

AU - Goto, Sataro

AU - Takahashi, Ryoya

AU - Kumiyama, Atsushi

AU - Radák, Zsolt

AU - Hayashi, Toshiaki

AU - Takenouchi, Masaki

AU - Abe, Ryoichi

PY - 2001

Y1 - 2001

N2 - Aging is characterized by accumulation of potentially harmful altered proteins that could lead to gradual deterioration of cellular functions and eventually result in increased probability of death. Metabolic turnover of proteins thus plays an essential role in maintaining the life of an organism. In this article we summarize our current knowledge on age-related changes in protein turnover with special reference to degradation. Increase in half-life of proteins with advancing age is well documented. Qualitative rather than quantitative changes of proteasomes appear to be responsible for this change. Dietary restriction and moderate long-term exercise seem to restore higher proteasome activity and turnover rate of proteins in aged animals.

AB - Aging is characterized by accumulation of potentially harmful altered proteins that could lead to gradual deterioration of cellular functions and eventually result in increased probability of death. Metabolic turnover of proteins thus plays an essential role in maintaining the life of an organism. In this article we summarize our current knowledge on age-related changes in protein turnover with special reference to degradation. Increase in half-life of proteins with advancing age is well documented. Qualitative rather than quantitative changes of proteasomes appear to be responsible for this change. Dietary restriction and moderate long-term exercise seem to restore higher proteasome activity and turnover rate of proteins in aged animals.

KW - Dietary restriction

KW - Exercise

KW - Hepatocytes

KW - Proteasomes

KW - Ubiquitin

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M3 - Article

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JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

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Implications of protein degradation in aging

Abstract

Keywords

ASJC Scopus subject areas

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