Improvement by guan-mu-tong (Caulis aristolochiae manshuriensis) of lactation in mice.

G. Wu*, K. Yamamoto, T. Mori, H. Inatomi, H. Nagasawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Free access of 0.5% Guan-mu-tong (Gmt) as drinking water inhibited lactation of mice estimated by pup growth rate, which was associated with a decrease in RNA content and RNA/DNA ratio in the mammary glands. 0.05% Gmt improved pup growth rate and mammary DNA content. No pups were lost during the experiment. Similar results were obtained by 0.5% Xia-ru-yong-quan-tang (Xryqt), a Chinese herbal medicine, which contained 0.05% Gmt. Xryqt further prevented a decline in ovarian weight seen by 0.05% Gmt treatment and significantly increased mother weight. These findings revealed two opposite effects of Gmt on mammary glands, stimulative and inhibitory, at low- and high-dose levels, respectively.

Original languageEnglish
Pages (from-to)159-165
Number of pages7
JournalAmerican Journal of Chinese Medicine
Issue number2
Publication statusPublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Complementary and alternative medicine


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