In-vivo imaging of a mouse by detecting bremsstrahlung X-rays from 14C using a La-GPS imaging system

Seiichi Yamamoto*, Hideki Tomita, Ryohei Terabayashi, Kenji Yoshida, Kouhei Nakanishi, Takako Furukawa, Kei Kamada, Akira Yoshikawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Imaging of 14C outside of the subject is considered to be difficult because it is a radionuclide that emits only low-energy beta particles. However, we found that bremsstrahlung X-rays form 14C could be imaged from outside of subjects and is thus applicable to in vivo small animal imaging. We developed a high-resolution low-energy X-ray imaging system using a (Gd, La)2Si2O7:Ce(La-GPS) plate combined with a flat panel photomultiplier tube (FP-PMT) for in vivo imaging of a mouse to detect the X-rays from a 14C solution administered. Without using a parallel hole collimator, accumulated 14C in the mouse’s abdomen was imaged in 1 min and dynamic in vivo imaging was possible although the spatial resolution was moderate. With a parallel hole collimator, 14C in the abdomen was obtained with a higher spatial resolution with a 60-min acquisition time. We conclude that in vivo imaging of 14C is possible by using the developed high-resolution La-GPS imaging system and may be promising for molecular imaging research.

Original languageEnglish
Pages (from-to)1436-1447
Number of pages12
JournalJournal of Nuclear Science and Technology
Issue number11
Publication statusPublished - 2022
Externally publishedYes


  • C
  • La-GPS
  • beta particles
  • bremsstrahlung X-ray
  • imaging
  • in vivo imaging

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Nuclear Energy and Engineering


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