TY - JOUR
T1 - In Vivo Redox-Responsive Sol-Gel/Gel-Sol Transition of Star Block Copolymer Solution Based on Ionic Cross-Linking
AU - Nakagawa, Yoshiyuki
AU - Ohta, Seiichi
AU - Sugahara, Akira
AU - Okubo, Masashi
AU - Yamada, Atsuo
AU - Ito, Taichi
N1 - Funding Information:
We offer our deepest thanks to Perstorp Japan Co., Ltd.. for supplying DPE, Shin-Nakamura Chemical Co., Ltd., for supplying OEGA Mitsubishi Chemical Corporation for supplying chelate resin, Chubu Chelest Co., Ltd., for supplying EDDS, and Nitto Denko Corporation for supplying the ultrafiltration membrane. We also thank Professor Tei/Chung and Associate Professor Sakai at The University of Tokyo for providing access to a rheometer. Y.N. appreciates a Research Fellowship from the Japan Society for the Promotion of Science (JSPS). This work was supported by a Grant-in-Aid for JSPS Research Fellow (No. 16J08368).
Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/7/25
Y1 - 2017/7/25
N2 - Redox-responsive hydrogels have the potential for application in various fields, including biomedical science. We have developed a redox-responsive star block copolymer hydrogel based on iron ion cross-linking. The addition of the ferric ion (Fe3+) induced gelation of the star block copolymer solution within a few seconds, whereas the addition of the ferrous ion (Fe2+) did not. The resulting hydrogels cross-linked using Fe3+ showed storage moduli (G′) of 26-1400 Pa and were stable under physiological conditions for as long as 1 month. The cross-linking between the star arms produced by the addition of Fe3+ enabled a fast, redox-responsive sol-gel/gel-sol transition. Furthermore, the hydrogel showed excellent injectability and biocompatibility in vivo, resulting in a rapid sol-gel/gel-sol transition in subcutaneous tissues in response to redox stimuli, such as the administration of ascorbic acid or hydrogen peroxide.
AB - Redox-responsive hydrogels have the potential for application in various fields, including biomedical science. We have developed a redox-responsive star block copolymer hydrogel based on iron ion cross-linking. The addition of the ferric ion (Fe3+) induced gelation of the star block copolymer solution within a few seconds, whereas the addition of the ferrous ion (Fe2+) did not. The resulting hydrogels cross-linked using Fe3+ showed storage moduli (G′) of 26-1400 Pa and were stable under physiological conditions for as long as 1 month. The cross-linking between the star arms produced by the addition of Fe3+ enabled a fast, redox-responsive sol-gel/gel-sol transition. Furthermore, the hydrogel showed excellent injectability and biocompatibility in vivo, resulting in a rapid sol-gel/gel-sol transition in subcutaneous tissues in response to redox stimuli, such as the administration of ascorbic acid or hydrogen peroxide.
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U2 - 10.1021/acs.macromol.7b01020
DO - 10.1021/acs.macromol.7b01020
M3 - Article
AN - SCOPUS:85026310706
SN - 0024-9297
VL - 50
SP - 5539
EP - 5548
JO - Macromolecules
JF - Macromolecules
IS - 14
ER -