TY - GEN
T1 - Increased cell functionalities with patterned co-cultures utilizing dual thermo-responsive polymer grafted surfaces
AU - Tsuda, Y.
AU - Kikuchi, A.
AU - Nakao, A.
AU - Yamato, M.
AU - Sakurai, Y.
AU - Umezu, M.
AU - Okano, T.
PY - 2004
Y1 - 2004
N2 - The impact of increased cell functionalities with patterned co-cultures was investigated by utilizing thermo-responsive hydrophilic property changes of poly(N-isopropylacrylamide) (PIPAAm). It was observed that regulating transition temperature of PIPAAm produce new culture for co-culture and in recovering co-cultured cell sheets. The cell functions were estimated by altering pattern sizes in the co-culture system. The results show that the stratification of co-cultured cell sheets leads to the creation of novel tissue constructs structurally similar to the native organs and tissues.
AB - The impact of increased cell functionalities with patterned co-cultures was investigated by utilizing thermo-responsive hydrophilic property changes of poly(N-isopropylacrylamide) (PIPAAm). It was observed that regulating transition temperature of PIPAAm produce new culture for co-culture and in recovering co-cultured cell sheets. The cell functions were estimated by altering pattern sizes in the co-culture system. The results show that the stratification of co-cultured cell sheets leads to the creation of novel tissue constructs structurally similar to the native organs and tissues.
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M3 - Conference contribution
AN - SCOPUS:13844257274
SN - 1877040193
SN - 9781877040191
T3 - Transactions - 7th World Biomaterials Congress
SP - 246
BT - Transactions - 7th World Biomaterials Congress
T2 - Transactions - 7th World Biomaterials Congress
Y2 - 17 May 2004 through 21 May 2004
ER -